Polymorphisms and haplotypes in the multidrug resistance 1 gene (MDR1/ABCB1) and risk of multiple myeloma

被引：34
|
作者：
Jamroziak, Krzysztof [1 ]
Balcerczak, Ewa [2 ]
Calka, Karolina [2 ]
Piaskowski, Sylwester [3 ]
Urbanska-Rys, Halina [1 ]
Salagacka, Aleksandra [2 ]
Mirowski, Marek [2 ]
Robak, Tadeusz [1 ]
机构：
[1] Med Univ Lodz, Dept Hematol, PL-93513 Lodz, Poland
[2] Med Univ Lodz, Lab Mol Biol & Pharmacogenom, Dept Pharmaceut Biochem, Lodz, Poland
[3] Med Univ Lodz, Dept Mol Pathol & Neuropathol, Lodz, Poland
来源：
LEUKEMIA RESEARCH | 2009年 / 33卷 / 02期
关键词：
P-glycoprotein; MDR1; ABCB1; SNP; Haplotype; Multiple myeloma; Genetic predisposition; MDR1; GENE; SUSCEPTIBILITY;
D O I：
10.1016/j.leukres.2008.06.008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MDR1(ABCB1) gene encodes Cor P-glycoprotein (P-gp, MDR1, ABCB1), an ATP-binding cassette superfamily member involved in the transport of xenobiotics. Here, we investigated whether common MDR1 single nucleotide polymorphisms (1236C>T, 2677G>A/T and 3435C>T) affect predisposition to multiple myeloma. Genotyping was performed in 111 myeloma patients and 96 controls by PCR-based assays. Haplotypes were inferred Using PHASE algorithm. We found comparable allele and genotype frequencies among myeloma patients and controls. Moreover, patient and control groups did not differ regarding MDR1 haplotype distribution (p = 0.18). In conclusion, our results do not support major influence of MDR1 variants oil the risk of myeloma in Caucasians. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：332 / 335
页数：4
相关论文
共 50 条
  • [31] The MDR1 (ABCB1) gene polymorphism and its clinical implications
    Ieiri, I
    Takane, H
    Otsubo, K
    CLINICAL PHARMACOKINETICS, 2004, 43 (09) : 553 - 576
  • [32] Is there evidence to claim or deny association between variants of the multidrug resistance gene (MDR1 or ABCB1) and inflammatory bowel disease?
    Zintzaras, Elias
    INFLAMMATORY BOWEL DISEASES, 2012, 18 (03) : 562 - 572
  • [33] Single nucleotide polymorphisms of multidrug resistance gene 1 (MDR1) and risk of chronic myeloid leukemia
    Yaya, Kassogue
    Hind, Dehbi
    Meryem, Quachouh
    Asma, Quessar
    Said, Benchekroun
    Sellama, Nadifi
    TUMOR BIOLOGY, 2014, 35 (11) : 10969 - 10975
  • [34] A Comprehensive Investigation on Common Polymorphisms in the MDR1/ABCB1 Transporter Gene and Susceptibility to Colorectal Cancer
    Campa, Daniele
    Sainz, Juan
    Pardini, Barbara
    Vodickova, Ludmila
    Naccarati, Alessio
    Rudolph, Anja
    Novotny, Jan
    Forsti, Asta
    Buch, Stephan
    von Schoenfels, Witigo
    Schafmayer, Clemens
    Voelzke, Henry
    Hoffmeister, Michael
    Frank, Bernd
    Barale, Roberto
    Hemminki, Kari
    Hampe, Jochen
    Chang-Claude, Jenny
    Brenner, Hermann
    Vodicka, Pavel
    Canzian, Federico
    PLOS ONE, 2012, 7 (03):
  • [35] Analyses of single nudleotide polymorphisms and haplotype linkage of the human ABCB1 (MDR1) gene in Korean
    Ryu, Ho-Cheol
    Kwon, Hyog-Young
    Choi, Il-Kuen
    Rhee, Dong-Kwon
    ARCHIVES OF PHARMACAL RESEARCH, 2006, 29 (12) : 1132 - 1139
  • [36] Up-regulation of multidrug resistance protein MDR1/ABCB1 in carfilzomib-resistant multiple myeloma differentially affects efficacy of anti-myeloma drugs
    Byrgazov, Konstantin
    Kraus, Marianne
    Besse, Andrej
    Slipicevic, Ana
    Lehmann, Fredrik
    Driessen, Christoph
    Besse, Lenka
    LEUKEMIA RESEARCH, 2021, 101
  • [37] Variable expression of P-glycoprotein in the human placenta and its association with mutations of the multidrug resistance 1 gene (MDR1, ABCB1)
    Hitzl, M
    Schaeffeler, E
    Hocher, B
    Slowinski, T
    Halle, H
    Eichelbaum, M
    Kaufmann, P
    Fritz, P
    Fromm, MF
    Schwab, M
    PHARMACOGENETICS, 2004, 14 (05): : 309 - 318
  • [38] The MDR1/ABCB1 gene rs 1045642 polymorphism in colorectal cancer
    Mrozikiewicz-Rakowska, Beata
    Malinowski, Marian
    Nehring, Piotr
    Bartkowiak-Wieczorek, Joanna
    Bogacz, Anna
    Zurawinska-Grzelka, Ewa
    Krasnodebski, Przemyslaw
    Muszynski, Jacek
    Grzela, Tomasz
    Przybylkowski, Adam
    Czupryniak, Leszek
    ARCHIVES OF MEDICAL SCIENCE, 2020, 16 (01) : 112 - 117
  • [39] Common germline MDR1/ABCB1 functional polymorphisms and haplotypes modify susceptibility to colorectal cancers with high microsatellite instability
    Potocnik, Uros
    Glavac, Damjan
    Dean, Michael
    CANCER GENETICS AND CYTOGENETICS, 2008, 183 (01) : 28 - 34
  • [40] The Relationship of ABCB1/MDR1 and CYP1A1 Variants with the Risk of Disease Development and Shortening of Overall Survival in Patients with Multiple Myeloma
    Zmorzynski, Szymon
    Wojcierowska-Litwin, Magdalena
    Popek-Marciniec, Sylwia
    Szudy-Szczyrek, Aneta
    Styk, Wojciech
    Chocholska, Sylwia
    Filip, Agata Anna
    JOURNAL OF CLINICAL MEDICINE, 2021, 10 (22)
12345