Oxazaborolidine-catalyzed enantioselective reduction of α-methylene ketones to allylic alcohols

被引：14

作者：

Matsuo, Jun-ichi ^{[1
]}

Kozai, Takaaki ^{[1
]}

Nishikawa, Osamu ^{[1
]}

Hattori, Yu ^{[1
]}

Ishibashi, Hiroyuki ^{[1
]}

机构：

[1] Kanazawa Univ, Grad Sch Nat Sci & Technol, Div Pharmaceut Sci, Kanazawa, Ishikawa 9201192, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 17期

关键词：

D O I：

10.1021/jo8011013

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxazaborolidine-catalyzed enantioselective reduction of a-methylene ketones was efficiently carried out by using borane-diethylaniline as a stoichiometric reducing agent. The combination of this method and subsequent hydrogenation of thus-formed allylic alcohol improved stereoselectivity in the reduction of 24-oxocholesteryl ester to 24-(R)-hydroxycholesteryl ester.

引用

页码：6902 / 6904

页数：3

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