Thermal-chemical flooding (TCF) is an effective alternative to enhance heavy oil recovery after steam injection. In this paper, single and parallel sand-pack flooding experiments were carried out to investigate the oil displacement ability of thermal-chemical composed of steam, nitrogen (N-2), and viscosity breaker (VB), considering multiple factors such as residual oil saturation (S-orw) postwater flood, scheme switch time, and permeability contrast. The results of single sand-pack experiments indicated that compared with steam flooding (SF), steam-nitrogen flooding, and steam-VB flooding, TCF had the best displacement efficiency, which was 11.7% higher than that of pure SF. The more serious of water-flooded degree, the poorer of TCF effect. The improvement effect of TCF almost lost as water saturation reached 80%. Moreover, the earlier TCF was transferred from steam injection, the higher oil recovery was obtained. The parallel sand-pack experiments suggested that TCF had good adaptability to reservoir heterogeneity. Emulsions generated after thermal-chemical injection diverted the following compound fluid turning to the low-permeable tube (LPT) due to its capturing and blocking ability. The expansion of N-2 and the disturbance of VB promoted oil recovery in both tubes. As reservoir heterogeneity became more serious, namely, permeability contrast was more than 6 in this study, the improvement effect became weaker due to earlier steam channeling in the high-permeable tube (HPT).