Cellular radiation effects and the bystander response

被引：100

作者：

Little, John B. ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Ctr Radiat Sci & Environm Hlth, Boston, MA 02115 USA

来源：

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 2006年 / 597卷 / 1-2期

关键词：

bystander effect; genomic instability; DNA repair; genetic susceptibility; gap junction intercellular communication; oxidative stress;

D O I：

10.1016/j.mrfmmm.2005.12.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

This report reviews briefly some of the findings reported over the past 2 years that enhance our understanding of the radiation-induced bystander effect. These developments include: technicological advances; the role of oxidative stress; the effect of cytoplasmic irradiation; cell-to-cell communication; and evidence that Connexin 43 mediated intercellular communication is induced by radiation exposure. A few overriding unanswered questions are discussed. These include: what is the signal(s) transmitted from irradiated to bystander cells; what is the relationship between the bystander response and other non-targeted effects of radiation; are there beneficial effects associated with the bystander response; and what is the significance of the bystander effect for radiation protection? (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：113 / 118

页数：6

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