Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-2

被引：85

作者：

Yu, Fei ^{[1
]}

Xiang, Rong ^{[1
]}

Deng, Xiaoqian ^{[1
]}

Wang, Lili ^{[2
]}

Yu, Zhengsen ^{[1
]}

Tian, Shijun ^{[1
]}

Liang, Ruiying ^{[1
]}

Li, Yanbai ^{[1
]}

Ying, Tianlei ^{[3
]}

Jiang, Shibo ^{[3
]}

机构：

[1] Hebei Agr Univ, Coll Life Sci, Baoding, Peoples R China

[2] Hebei Agr Univ, Res Ctr Chinese Jujube, Baoding, Peoples R China

[3] Fudan Univ, Sch Basic Med Sci, CAMS, Key Lab Med Mol Virol,MOE,NHC, Shanghai, Peoples R China

来源：

SIGNAL TRANSDUCTION AND TARGETED THERAPY | 2020年 / 5卷 / 01期

基金：

中国国家自然科学基金;

关键词：

ACUTE RESPIRATORY SYNDROME; CORONAVIRUS SPIKE PROTEIN; POTENT NEUTRALIZATION; VIRUS; IMMUNOPROPHYLAXIS; IDENTIFICATION; GENERATION; EPITOPES; FRAGMENT; VACCINE;

D O I：

10.1038/s41392-020-00318-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The outbreaks of severe acute respiratory syndrome (SARS) and Coronavirus Disease 2019 (COVID-19) caused by SARS-CoV and SARS-CoV-2, respectively, have posed severe threats to global public health and the economy. Treatment and prevention of these viral diseases call for the research and development of human neutralizing monoclonal antibodies (NMAbs). Scientists have screened neutralizing antibodies using the virus receptor-binding domain (RBD) as an antigen, indicating that RBD contains multiple conformational neutralizing epitopes, which are the main structural domains for inducing neutralizing antibodies and T-cell immune responses. This review summarizes the structure and function of RBD and RBD-specific NMAbs against SARS-CoV and SARS-CoV-2 currently under development.

引用

页数：12

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