In vitro activities of the des-fluoro(6) quinolone BMS-284756 against aerobic and anaerobic pathogens isolated from skin and soft tissue animal and human bite wound infections

被引：17
|
作者：
Goldstein, EJC
Citron, DM
Merriam, CV
Warren, YA
Tyrrell, KL
Fernandez, H
机构：
[1] Univ Calif Los Angeles, Med Ctr, RM Alden Res Lab, Santa Monica, CA 90404 USA
[2] Univ Calif Los Angeles, Sch Med, Los Angeles, CA 90073 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 03期
关键词：
D O I：
10.1128/AAC.46.3.866-870.2002
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
BMS-284756, a new des-fluoro(6) quinolone, was very active against 240 aerobic and 180 anaerobic isolates from bite victims. It inhibited 403 of 420 (96%) isolates, including those of Maraxella spp., CDC group EF-4, and Eikenella corrodens at less than or equal to2 mug/ml and those of all Pasteurella spp. and Bergeyella zoohelcum at less than or equal to0.015 mug/ml. Fusobacterium russii and 6 of 11 Fusobacterium nucleatum isolates of animal bite origin were resistant, but isolates of human bite origin were susceptible, which suggests that they were of a different subspecies.
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页码：866 / 870
页数：5
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