In Vitro Trypanocidal Activity of Ergosterol and Cholesterol Derivative Compounds

被引：0

作者：

Lobato-Tapia, Carlos A. ^{[2
]}

Ramos-Ligonio, Angel ^{[1
,2
]}

Lopez-Monteon, Aracely ^{[1
,2
]}

Mansilla, Horacio ^{[3
]}

Trigos, Angel ^{[2
,4
]}

机构：

[1] Univ Veracruzana, Fac Ciencias Quim, LADISER Inmunol & Biol Mol, Orizaba, Veracruz, Mexico

[2] Univ Veracruzana, Ctr Invest Biomed, Xalapa 91000, Veracruz, Mexico

[3] CSIC, Inst Prod Nat & Agrobiol, Tenerife 38204, Spain

[4] Univ Veracruzana, Lab Alta Tecnol Xalapa, Xalapa 91010, Veracruz, Mexico

来源：

LATIN AMERICAN JOURNAL OF PHARMACY | 2012年 / 31卷 / 08期

关键词：

Dehydrocholesterol peroxide; Ergosterol peroxide; Ergosterol peroxide acetate; Trypanocidal activity;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chagas' disease, caused by the protozoan parasite Trypanosoma cruzi, affects 9-12 million of people in Latin America and it is an important cause of heart disease. Due to the magnitude of the problem, finding a cure for this disease remains a major challenge. In the present study we report the trypanocidal activity of ergosterol peroxide acetate as well as of dehydrocholesterol peroxide. The results demonstrated that ergosterol peroxide acetate and dehydrocholesterol peroxide have IC50 values of 41.57 and 17.57 mu g/mL respectively, and show acceptable values of citotoxicity. These compounds emerges as promising candidates for further testing as anti-T, cruzi agents due to their selectivity for the parasite plasma membrane.

引用

页码：1126 / 1131

页数：6

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