Phase I study of doxorubicin (D) plus anti-insulin-like growth factor 1 receptor (IGF-1R) antibody cixutumumab (IMC-A12) in advanced soft tissue sarcoma (STS)

被引：0
|
作者：
Chugh, Rashmi
Griffith, Kent A.
Brockstein, Bruce
Undevia, Samir D.
Stadler, Walter Michael
Schuetze, Scott
机构：
[1] Univ Michigan, Ann Arbor, MI 48109 USA
[2] NorthShore Univ HealthSyst, Chicago, IL USA
[3] Univ Chicago, Chicago, IL 60637 USA
来源：
JOURNAL OF CLINICAL ONCOLOGY | 2012年 / 30卷 / 15期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
10028
引用
收藏
页数：1
相关论文
共 50 条
  • [21] A phase I study of R1507, a human monoclonal antibody IGF-1R (insulin-like growth factor receptor) antagonist in patients with advanced solid tumors
    Gore, Lia
    Aisner, Joseph
    Kurzrock, Razelle
    McCarthy, Cinara D.
    Winter, Erica
    Grippe, Joseph
    Frankel, Stanley
    Mita, Alain
    MOLECULAR CANCER THERAPEUTICS, 2009, 8 (12)
  • [22] Insulin growth factor receptor (IGF-1R) antibody cixutumumab combined with the mTOR inhibitor temsirolimus in patients with refractory Ewing's sarcoma family tumors
    Naing, Aung
    LoRusso, Patricia
    Subbiah, Vivek
    Fu, Siqing
    Hong, David
    Anderson, Peter
    Benjamin, Robert
    Ludwig, Joseph
    Chen, Helen X.
    Doyle, Austin
    Kurzrock, Razelle
    CANCER RESEARCH, 2012, 72
  • [23] A phase I, first in man study of weekly IMC-A12, a fully human insulin like growth factor-I receptor IgG1 monoclonal antibody, in patients with advanced solid tumors
    Higano, C. S.
    Yu, E. Y.
    Whiting, S. H.
    Gordon, M. S.
    LoRusso, P.
    Fox, F.
    Katz, T. L.
    Roecker, J. M.
    Schwartz, J. D.
    JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (18)
  • [24] Insulin growth factor receptor (IGF-1R) antibody cixutumumab combined with the mTOR inhibitor temsirolimus in patients with metastatic adrenocortical carcinoma
    A Naing
    P LoRusso
    S Fu
    D Hong
    H X Chen
    L A Doyle
    A T Phan
    M A Habra
    R Kurzrock
    British Journal of Cancer, 2013, 108 : 826 - 830
  • [25] A phase I dose-escalation study of weekly IMC-A12, a fully human insulin like growth factor-1 receptor (IGF-IR) IgG1 monoclonal antibody (Mab), in patients (pts) with advanced cancer
    Higano, C.
    Gordon, M.
    LoRusso, R.
    Fox, F.
    Katz, T.
    Roecker, J.
    Rowinsky, E.
    Youssoufian, H.
    EJC SUPPLEMENTS, 2006, 4 (12): : 195 - 195
  • [26] Insulin growth factor receptor (IGF-1R) antibody cixutumumab combined with the mTOR inhibitor temsirolimus in patients with metastatic adrenocortical carcinoma
    Naing, A.
    LoRusso, P.
    Fu, S.
    Hong, D.
    Chen, H. X.
    Doyle, L. A.
    Phan, A. T.
    Habra, M. A.
    Kurzrock, R.
    BRITISH JOURNAL OF CANCER, 2013, 108 (04) : 826 - 830
  • [27] Development and preclinical evaluation of cixutumumab drug conjugates in a model of insulin growth factor receptor I (IGF-1R) positive cancer
    Viswas Raja Solomon
    Elahe Alizadeh
    Wendy Bernhard
    Amal Makhlouf
    Siddesh V. Hartimath
    Wayne Hill
    Ayman El-Sayed
    Kris Barreto
    Clarence Ronald Geyer
    Humphrey Fonge
    Scientific Reports, 10
  • [28] Insulin Growth Factor-Receptor (IGF-1R) Antibody Cixutumumab Combined with the mTOR Inhibitor Temsirolimus in Patients with Refractory Ewing's Sarcoma Family Tumors
    Naing, Aung
    LoRusso, Patricia
    Fu, Siqing
    Hong, David S.
    Anderson, Pete
    Benjamin, Robert S.
    Ludwig, Joseph
    Chen, Helen X.
    Doyle, Laurence A.
    Kurzrock, Razelle
    CLINICAL CANCER RESEARCH, 2012, 18 (09) : 2625 - 2631
  • [29] Development and preclinical evaluation of cixutumumab drug conjugates in a model of insulin growth factor receptor I (IGF-1R) positive cancer
    Solomon, Viswas Raja
    Alizadeh, Elahe
    Bernhard, Wendy
    Makhlouf, Amal
    Hartimath, Siddesh V.
    Hill, Wayne
    El-Sayed, Ayman
    Barreto, Kris
    Geyer, Clarence Ronald
    Fonge, Humphrey
    SCIENTIFIC REPORTS, 2020, 10 (01)
  • [30] Preliminary Efficacy of the Anti-Insulin-Like Growth Factor Type 1 Receptor Antibody Figitumumab in Patients With Refractory Ewing Sarcoma
    Juergens, Heribert
    Daw, Najat C.
    Geoerger, Birgit
    Ferrari, Stefano
    Villarroel, Milena
    Aerts, Isabelle
    Whelan, Jeremy
    Dirksen, Uta
    Hixon, Mary L.
    Yin, Donghua
    Wang, Tao
    Green, Stephanie
    Paccagnella, Luisa
    Gualberto, Antonio
    JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (34) : 4534 - 4540
12345