Preparation and synthetic applications of (S)- and (R)-N-Boc-N,O-isopropylidene-α-methylserinals:: Asymmetric synthesis of (S)- and (R)-2-amino-2-methylbutanoic acids (Iva)

被引：39

作者：

Avenoza, A ^{[1
]}

Cativiela, C

Corzana, F

Peregrina, JM

Zurbano, MM

机构：

[1] Univ La Rioja, Dept Quim Quim Organ, Logrono 26001, Spain

[2] Univ Zaragoza, CSIC, Inst Ciencia Mat Aragon, Dept Quim Organ, E-50009 Zaragoza, Spain

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1999年 / 64卷 / 22期

关键词：

D O I：

10.1021/jo990957o

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This report describes an efficient and convenient large-scale synthesis procedure for (S)- and (R)-N-Boc-alpha-methylserinal acetonides (3 and 4) starting from (R)-2-methylglycidol 5. The application of both of these compounds as valuable chiral building blocks in the asymmetric synthesis of alpha-methylamino acids is also demonstrated by the synthesis of(S)- and (R)-isovalines (Iva) (6 and 7).

引用

页码：8220 / 8225

页数：6

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