A New Xanthone O-Glycoside from the Mangrove Endophytic Fungus Phomopsis sp.

被引：14
|
作者：
Huang, Zhongjing [1 ]
Yang, Jianxiang [2 ]
Lei, Fuhou [1 ]
She, Zhigang [3 ]
Lin, Yongcheng [3 ]
机构：
[1] Guangxi Univ Nationalities, Coll Chem & Ecol Engn, Nanning 530006, Peoples R China
[2] Guilin Med Univ, Dept Chem & Engn, Guilin 541004, Peoples R China
[3] Sun Yat Sen Zhongshan Univ, Coll Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2013年 / 49卷 / 01期
基金：
中国国家自然科学基金;
关键词：
xanthone O-glycoside; mangrove endophytic fungus; structure elucidation; cytotoxic activity; SOUTH CHINA SEA; METABOLITES; ROOTS;
D O I：
10.1007/s10600-013-0497-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new xanthone O-glycoside, 3-O-(6-O-alpha-L-arabinopyranosyl)-beta-D-glucopyranosyl-1,4-dimethoxyxanthone (1), together with three known compounds, phomapyrone D (2), 2-methoxy-3,4-methylenedioxybenzophenone (3), and cyclo(D-6-Hyp-L-Phe) (4), was isolated from the mangrove endophytic fungus, Phomopsis sp. (ZH76). Their structures were determined by analysis of spectroscopic data. Compound 1 inhibited HEp-2 and HepG2 cells with IC50 values of 9 and 16 mu mol/mL, respectively.
引用
收藏
页码：27 / 30
页数：4
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