Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with TH2-driven asthma

被引：41

作者：

Homburg, Ursula ^{[1
]}

Renz, Harald ^{[2
,3
]}

Timmer, Wolfgang

Hohlfeld, Jens M. ^{[4
]}

Seitz, Friedeborg ^{[5
]}

Lueer, Katrin ^{[4
]}

Mayer, Alexandra ^{[5
]}

Wacker, Anja ^{[6
]}

Schmidt, Oliver ^{[6
]}

Kuhlmann, Jens ^{[1
]}

Turowska, Agnieszka ^{[1
]}

Roller, Julia ^{[7
]}

Kutz, Klaus ^{[8
]}

Schlueter, Gerhard

Krug, Norbert ^{[4
]}

Garn, Holger ^{[2
,3
]}

机构：

[1] Sterna Biol GmbH, Marburg, Germany

[2] Univ Giessen, Univ Marburg, Fac Med, Inst Lab Med & Pathobiochem Mol Diagnost, Marburg, Germany

[3] Marburg Lung Ctr UGMLC, Marburg, Germany

[4] Fraunhofer Inst Toxicol & Expt Med, Dept Clin Airway Res, Hannover, Germany

[5] CRS Clin Res Serv Mannheim GmbH, Mannheim, Germany

[6] Engelhard Arzneimittel GmbH, Niederdorfelden, Germany

[7] Vectura GmbH, Gauting, Germany

[8] AccelPharm, Basel, Switzerland

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2015年 / 136卷 / 03期

关键词：

GATA-3-SPECIFIC DNAZYME; ACTIVATION; EXPRESSION; TOXICITY; EXPOSURE; HGD40;

D O I：

10.1016/j.jaci.2015.02.018

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

[No abstract available]

引用

页码：797 / +

页数：4

共 41 条

[21] Efficacy and safety of single inhaled doses of LAS100977, a novel long acting β2-agonist in patients with persistent asthma
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AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2010, 181
[22] Efficacy, Safety And Tolerability Of Abediterol (las100977), A Novel Long Acting β2-Adrenergic Agonist, In Patients With Persistent Asthma
Beier, J.
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De Miquel, G.
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AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2014, 189
[23] T-bet/GATA-3 ratio is a surrogate measure of Th1/Th2 cytokine profiles and may be novel targets for CpG ODN treatment in asthma patients
DONG Liang
中华医学杂志(英文版), 2006, (16) : 1396 - 1399
[24] T-bet/GATA-3 ratio is a surrogate measure of Th1/Th2 cytokine profiles and may be novel targets for CpG ODN treatment in asthma patients
Dong Liang
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Li Li-zheng
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CHINESE MEDICAL JOURNAL, 2006, 119 (16) : 1396 - 1399
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EUROPEAN RESPIRATORY JOURNAL, 2012, 40
[26] Characterisation of pharmacokinetics, safety and tolerability in a first-in-human study for AZD8154, a novel inhaled selective PI3Kγδ dual inhibitor targeting airway inflammatory disease
Sadiq, Muhammad Waqas
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BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2022, 88 (01) : 260 - 270
[27] Tolerability of indacaterol, a novel once-daily β2-agonist, in patients with asthma:: a randomized, placebo-controlled, 28-day safety study
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[28] Novel immunostimulators with a thiazolidin-4-one ring promote the immunostimulatory effect of human iNKT cells on the stimulation of Th2-like immune responsiveness via GATA3 activation in vitro
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Yang, Fei
Chen, Hua
Li, Xiaoliu
Yang, Yongbin
Chen, Dongzhi
INTERNATIONAL IMMUNOPHARMACOLOGY, 2016, 39 : 353 - 358
[29] Picroside II Attenuates Airway Inflammation by Downregulating the Transcription Factor GATA3 and Th2-Related Cytokines in a Mouse Model of HDM-Induced Allergic Asthma (vol 11, e0167098, 2016)
Choi, Jin
Choi, Bo Kyong
Kim, Jin Seok
Lee, Jae-Won
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Lee, Hyun-Jun
PLOS ONE, 2017, 12 (01):
[30] PSORI-CM02 alleviates IMQ-induced mouse dermatitis via differentially regulating pro- and anti-inflammatory cytokines targeting of Th2 specific transcript factor GATA3
Wu, Ding-hong
Zhang, Miao-miao
Li, Ning
Li, Xiong
Cai, Quan-wei
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Liu, Li-ping
Zhu, Wei
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