Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with TH2-driven asthma

被引：41
|
作者：
Homburg, Ursula [1 ]
Renz, Harald [2 ,3 ]
Timmer, Wolfgang
Hohlfeld, Jens M. [4 ]
Seitz, Friedeborg [5 ]
Lueer, Katrin [4 ]
Mayer, Alexandra [5 ]
Wacker, Anja [6 ]
Schmidt, Oliver [6 ]
Kuhlmann, Jens [1 ]
Turowska, Agnieszka [1 ]
Roller, Julia [7 ]
Kutz, Klaus [8 ]
Schlueter, Gerhard
Krug, Norbert [4 ]
Garn, Holger [2 ,3 ]
机构：
[1] Sterna Biol GmbH, Marburg, Germany
[2] Univ Giessen, Univ Marburg, Fac Med, Inst Lab Med & Pathobiochem Mol Diagnost, Marburg, Germany
[3] Marburg Lung Ctr UGMLC, Marburg, Germany
[4] Fraunhofer Inst Toxicol & Expt Med, Dept Clin Airway Res, Hannover, Germany
[5] CRS Clin Res Serv Mannheim GmbH, Mannheim, Germany
[6] Engelhard Arzneimittel GmbH, Niederdorfelden, Germany
[7] Vectura GmbH, Gauting, Germany
[8] AccelPharm, Basel, Switzerland
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2015年 / 136卷 / 03期
关键词：
GATA-3-SPECIFIC DNAZYME; ACTIVATION; EXPRESSION; TOXICITY; EXPOSURE; HGD40;
D O I：
10.1016/j.jaci.2015.02.018
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
[No abstract available]
引用
收藏
页码：797 / +
页数：4
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