Structure and mucosal adjuvanticity of cholera and Escherichia coli heat-labile enterotoxins

被引：226
|
作者：
Rappuoli, R
Pizza, M
Douce, G
Dougan, G
机构：
[1] Chiron SPA, IRIS, I-53100 Siena, Italy
[2] Univ London Imperial Coll Sci Technol & Med, Dept Biochem, London SW7 2AZ, England
来源：
IMMUNOLOGY TODAY | 1999年 / 20卷 / 11期
关键词：
D O I：
10.1016/S0167-5699(99)01523-6
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Escherichia coli heat-labile enterotoxin and cholera toxin are potent mucosal immunogens and adjuvants in animal models. Nontoxic mutants retaining adjuvant activity are useful tools to dissect the mechanism of mucosal adjuvanticity and promising candidates far development of human vaccines and immunotherapy. Clinical trials are expected to proceed in the near future.
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页码：493 / 500
页数：8
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