A new reagent and its polymer-supported variant for the amidination of amines

被引：26

作者：

Dräger, G

Solodenko, W

Messinger, J

Schön, U

Kirschning, A

机构：

[1] Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany

[2] Solvay Pharmaceut GMBH, D-30173 Hannover, Germany

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(01)02403-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New reagents tor the high yielding amidination of primary and secondary amines are described. By attaching a benzyl substituent to the 3,5-dimethyl-1H-pyrazole-1-carboxamidine ring. a reagent 1 is obtained which allows easy work-up after amidination because of solubility of byproducts in organic solvents. In addition. the polystyrene-bound analogue 2 was prepared which allows amidination of various amines with high purity. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：1401 / 1403

页数：3

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