A new reagent and its polymer-supported variant for the amidination of amines

被引：26
|
作者：
Dräger, G
Solodenko, W
Messinger, J
Schön, U
Kirschning, A
机构：
[1] Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany
[2] Solvay Pharmaceut GMBH, D-30173 Hannover, Germany
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 08期
关键词：
D O I：
10.1016/S0040-4039(01)02403-0
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
New reagents tor the high yielding amidination of primary and secondary amines are described. By attaching a benzyl substituent to the 3,5-dimethyl-1H-pyrazole-1-carboxamidine ring. a reagent 1 is obtained which allows easy work-up after amidination because of solubility of byproducts in organic solvents. In addition. the polystyrene-bound analogue 2 was prepared which allows amidination of various amines with high purity. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1401 / 1403
页数：3
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