The Calcium Channel Blocker Bepridil Demonstrates Efficacy in the Murine Model of Marburg Virus Disease

被引：19

作者：

DeWald, Lisa Evans ^{[1
,3
]}

Dyall, Julie ^{[1
]}

Sword, Jennifer M. ^{[1
]}

Torzewski, Lisa ^{[1
]}

Zhou, Huanying ^{[1
]}

Postnikova, Elena ^{[1
]}

Kollins, Erin ^{[1
]}

Alexander, Isis ^{[1
]}

Gross, Robin ^{[1
]}

Cong, Yu ^{[1
]}

Gerhardt, Dawn M. ^{[1
]}

Johnson, Reed F. ^{[2
]}

Olinger, Gene G., Jr. ^{[1
,4
]}

Holbrook, Michael R. ^{[1
]}

Hensley, Lisa E. ^{[1
]}

Jahrling, Peter B. ^{[1
,2
]}

机构：

[1] NIAID, Integrated Res Facil, NIH, B-8200 Res Plaza, Frederick, MD 21702 USA

[2] NIAID, Emerging Viral Pathogens Sect, NIH, Frederick, MD USA

[3] Emergent BioSolut Inc, Gaithersburg, MD USA

[4] MRIGlobal Global Hlth Surveillance & Diagnost, Gaithersburg, MD USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2018年 / 218卷

关键词：

antiviral; bepridil; Marburg virus; GLYCOPROTEIN; AMIODARONE; TARGET; EBOLA;

D O I：

10.1093/infdis/jiy332

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

No therapeutics are approved for the treatment of filovirus infections. Bepridil, a calcium channel blocker developed for treating angina, was identified as a potent inhibitor of filoviruses in vitro, including Ebola and Marburg viruses, and Ebola virus in vivo. We evaluated the efficacy of bepridil in a lethal mouse model of Marburg virus disease. A dose of 12 mg/kg bepridil once or twice daily resulted in 80% or 90% survival, respectively. These data confirm bepridil's broad-spectrum anti-filovirus activity warranting further investigation of bepridil, or improved compounds with a similar mechanism, as a pan-filovirus therapeutic agent.

引用

页码：S588 / S591

页数：4

共 50 条

[31] Effects of calcium channel blocker on TNF-α in rat model of liver transplantation
Liu, HT
Li, YG
PROCEEDINGS OF THE 2003 SYMPOSIUM OF CHINA POSTDOCTORS AND ACADEMICIANS ON LIFE SCIENCE, 2003, : 253 - 257
[32] Effect of an angiotensin II receptor blocker and a calcium channel blocker on hypertension associated penile dysfunction in a rat model
Shimizu, Shogo
Tsounapi, Panagiota
Honda, Masashi
Dimitriadis, Fotios
Taniuchi, Keisuke
Shimizu, Takahiro
Inoue, Keiji
Saito, Motoaki
BIOMEDICAL RESEARCH-TOKYO, 2014, 35 (03): : 215 - 221
[33] Synergistic antinociceptive effect of a calcium channel blocker and a TRPV1 blocker in an acute pain model in mice
Palhares, Manuella R.
Silva, Juliana F.
Rezende, Marcio Junior S.
Santos, Duana C.
Silva-Junior, Claudio A.
Borges, Marcia H.
Ferreira, Juliano
Gomez, Marcus V.
Castro-Junior, Celio J.
LIFE SCIENCES, 2017, 182 : 122 - 128
[34] A mathematical model of Marburg virus disease outbreaks and the potential role of vaccination in control
George Y. Qian
W. John Edmunds
Daniel G. Bausch
Thibaut Jombart
BMC Medicine, 21
[35] The PIM kinase inhibitor TP-3654 demonstrates efficacy in a murine model of myelofibrosis
Dutta, Avik
Nath, Dipmoy
Yang, Yue
Mohi, Golam
CANCER RESEARCH, 2018, 78 (13)
[36] A mathematical model of Marburg virus disease outbreaks and the potential role of vaccination in control
Qian, George Y.
Edmunds, W. John
Bausch, Daniel G.
Jombart, Thibaut
BMC MEDICINE, 2023, 21 (01)
[37] A COMPARISON OF THE EFFICACY AND SAFETY OF A BETA-BLOCKER, A CALCIUM-CHANNEL BLOCKER, AND A CONVERTING-ENZYME-INHIBITOR IN HYPERTENSIVE BLACKS
SAUNDERS, E
WEIR, MR
KONG, BW
HOLLIFIELD, J
GRAY, J
VERTES, V
SOWERS, JR
ZEMEL, MB
CURRY, C
SCHOENBERGER, J
WRIGHT, JT
KIRKENDALL, W
CONRADI, EC
JENKINS, P
MCLEAN, B
MASSIE, B
BERENSON, G
FLAMENBAUM, W
ARCHIVES OF INTERNAL MEDICINE, 1990, 150 (08) : 1707 - 1713
[38] To Compare the Efficacy of Beta Agonist Ritodrine and Calcium Channel Blocker Nifedipine in the Management of Preterm Labour
Ali, Memoona
Hussain, Muhammad Arshad
Qaisrani, Hani Gull
Chohan, Muhammad Arshad
PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES, 2013, 7 (04): : 1167 - 1169
[39] Does Therapeutic Hypothermia Decrease Efficacy of Hyperinsulinemia Therapy in Calcium-Channel Blocker Toxicity?
Smelski, Geoffrey
Watkins, Sarah
CLINICAL TOXICOLOGY, 2019, 57 (10) : 977 - 978
[40] The Safety and Efficacy of the Calcium Channel Blocker (CCB) Amlodipine in the Treatment of Secondary Hypertension in Children † 1806
Jeremy J Gitomer
Ellen M Grimm
Melvin A Bonilla-Felix
Rita D Swinford
Maria E Ferris
Ronald J Portman
Pediatric Research, 1998, 43 (Suppl 4) : 308 - 308

← 1 2 3 4 5 →