Delayed Effects of NMDA Receptor Antagonist MK-801 on Storage and Reconsolidation of Spatial Memory in Rats

被引：1
|
作者：
Storozheva, Z. I. [1 ]
Solovieva, O. A. [1 ]
Proshin, A. T. [1 ]
Sherstnev, V. V. [1 ]
机构：
[1] Russian Acad Med Sci, PK Anokhin Inst Normal Physiol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2012年 / 153卷 / 05期
关键词：
glutamate NMDA glutamat receptors; MK-801; learning; spatial memory; rats; ADULT HIPPOCAMPAL NEUROGENESIS; FIBROBLAST GROWTH FACTOR-2; CONDITIONED FEAR; EXTINCTION; FACILITATE; MODEL;
D O I：
10.1007/s10517-012-1777-6
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effects of NMDA receptor antagonist MK-801 on the storage and reconsolidation of spatial memory in Morris water maze in adult rats. MK-801 (50 mu g/kg) administered 24 h after the completion of training was shown to improve the resistance of spatial memory to spontaneous extinction, while reminder against the background of MK-801 suppresses its ameliorating effect on memory storage. The detected behavioral effects of MK-801 persisted over 60 days after administration and can be associated with its influence on coupled neurogenesis/apoptosis processes induced during memory trace formation in adult animals.
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页码：605 / 608
页数：4
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