Interventions to address potentially inappropriate prescriptions and over-the-counter medication use among adults 65 years and older in primary care settings: protocol for a systematic review

被引：1

作者：

Beck, Andrew ^{[1
]}

Persaud, Navindra ^{[2
]}

Tessier, Laure A. ^{[3
]}

Grad, Roland ^{[4
]}

Kidd, Michael R. ^{[5
,6
]}

Klarenbach, Scott ^{[7
]}

Korownyk, Christina ^{[8
]}

Moore, Ainsley ^{[9
]}

Thombs, Brett D. ^{[10
,11
]}

Mangin, Dee ^{[9
,12
]}

McCracken, Rita K. ^{[13
]}

McDonald, Emily G. ^{[14
]}

Sirois, Caroline ^{[15
,16
]}

Kanji, Salmaan ^{[17
]}

Molnar, Frank ^{[18
,19
]}

Nicholls, Stuart G. ^{[20
]}

Thavorn, Kednapa

Bennett, Alexandria ^{[1
]}

Shaver, Nicole ^{[1
]}

Skidmore, Becky

Mitchelmore, Bradley R. ^{[3
]}

Avey, Marc ^{[3
]}

Rolland-Harris, Elizabeth ^{[3
]}

Little, Julian ^{[1
]}

Moher, David ^{[1
]}

机构：

[1] Univ Ottawa, Fac Med, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada

[2] St Michaels Hosp, Dept Family & Community Med, Toronto, ON, Canada

[3] Publ Hlth Agcy Canada, Global Hlth & Guidelines Div, Ottawa, ON, Canada

[4] McGill Univ, Dept Family Med, Montreal, PQ, Canada

[5] Australian Natl Univ, Coll Hlth & Med, Canberra, ACT, Australia

[6] Univ Toronto, Dept Family & Community Med, Toronto, ON, Canada

[7] Univ Alberta, Dept Med & Dent, Edmonton, AB, Canada

[8] Univ Alberta, Dept Family Med, Edmonton, AB, Canada

[9] McMaster Univ, Dept Family Med, Hamilton, ON, Canada

[10] McGill Univ, Lady Davis Inst, Jewish Gen Hosp, Montreal, PQ, Canada

[11] McGill Univ, Fac Med, Montreal, PQ, Canada

[12] Univ Otago, Dept Gen Practice, Dunedin, New Zealand

[13] Univ British Columbia, Dept Family Practice, Vancouver, BC, Canada

[14] McGill Univ, Dept Med, Hlth Ctr, Montreal, PQ, Canada

[15] Laval Univ, Fac Pharm, Quebec City, PQ, Canada

[16] VITAM Res Ctr, Ctr Excellence Vieillissement Quebec, Quebec City, PQ, Canada

[17] Ottawa Hosp, Res Inst, Ottawa, ON, Canada

[18] Univ Ottawa, Fac Med, Ottawa, ON, Canada

[19] Ottawa Hosp, Res Inst, Bruyere Res Inst, Div Geriatr Med, Ottawa, ON, Canada

[20] Ottawa Hosp, Clin Epidemiol Program, Res Inst, Ottawa, ON, Canada

来源：

SYSTEMATIC REVIEWS | 2022年 / 11卷 / 01期

关键词：

Inappropriate prescribing; Over-the-counter medication; Polypharmacy; Systematic review; Older adults; L Guideline; Primary health care; AHRQ SERIES; HEALTH-CARE; QUALITY; PHARMACOTHERAPY; POLYPHARMACY; METAANALYSIS; GUIDELINES; CRITERIA;

D O I：

10.1186/s13643-022-02044-w

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose: To inform recommendations by the Canadian Task Force on Preventive Health Care on potentially inappropriate prescribing and over-the-counter (OTC) medication use among adults aged 65 years and older in primary care settings. This protocol outlines the planned scope and methods for a systematic review of the benefits and harms and acceptability of interventions to reduce potentially inappropriate prescriptions and OTC medication use. Methods: De novo systematic reviews will be conducted to synthesize the available evidence on (a) the benefits and harms of interventions to reduce potentially inappropriate prescriptions and OTC medications compared to no intervention, usual care, or non- or minimally active intervention among adults aged 65 years and older and (b) the acceptability of these interventions or attributes among patients. Outcomes of interest for the benefits and harms review are all-cause mortality, hospitalization, non-serious adverse drug reactions, quality of life, emergency department visits, injurious falls, medical visits, and the number of medications (and number of pills). Outcomes for the acceptability review are the preference for and relative importance of different interventions or their attributes. For the benefits and harms review, we will search MEDLINE, Embase, and Cochrane Central Register of Controlled Trials for randomized controlled trials. For the acceptability review, we will search MEDLINE, Embase, PsycInfo, Cochrane Central Register of Controlled Trials, and the NHS Economic Evaluation Database for experimental and observational studies with a comparator. Websites of relevant organizations, other grey literature sources, and reference lists of included studies and reviews will be searched. Title and abstract screening will be completed by two independent reviewers using the liberal accelerated approach. Full-text review, data extraction, risk of bias assessments, and GRADE (Grading of Recommendations Assessment, Development and Evaluation) will be completed independently by two reviewers, with any disagreements resolved by consensus or by consulting with a third reviewer. The GRADE approach will be used to assess the certainty of the evidence for outcomes. Discussion: The results of this systematic review will be used by the Canadian Task Force on Preventive Health Care to inform their recommendation on potentially inappropriate prescribing and OTC medication use among adults aged 65 years and older.

引用

页数：14

共 41 条

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