A Review on the Development in the Field of NIDDM based Thiazolidinedione PPARγ Agonists

被引：0
|
作者：
Banerjee, Pooja S. [1 ]
Samanta, Subir [1 ]
机构：
[1] Birla Inst Technol, Dept Pharmaceut Sci, Ranchi, Bihar, India
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2013年 / 13卷 / 05期
关键词：
Natural ligands; Pharmacophore; PPAR gamma; Synthetic ligands; Thiazolidinediones; Type II Diabetes; LIGAND-BINDING; HYPOLIPIDEMIC AGENTS; BIOLOGICAL-ACTIVITY; CRYSTAL-STRUCTURE; RECEPTOR; ALPHA; ROSIGLITAZONE; GLITAZONES; SERIES; LIVER;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Peroxisome Proliferator Activated Receptors gamma (PPAR) are a class of ligand activated transcription factors with a prominent role in the regulation of metabolic processes. The present work aims towards examining the functional and structural features that facilitate the binding of small molecules based on Thiazolidinedione pharmacophore to PPARs. The intent of this article is to review all the reported thiazolidinediones and associated groups of PPAR gamma ligands.
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页码：706 / 712
页数：7
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