Management of Neurogenic Orthostatic Hypotension in Patients with Autonomic Failure

被引：22
|
作者：
Schroeder, Christoph [1 ]
Jordan, Jens [1 ]
Kaufmann, Horacio [2 ]
机构：
[1] Hannover Med Sch, Inst Clin Pharmacol, D-30625 Hannover, Germany
[2] NYU, Sch Med, Dysauton Res Lab, New York, NY USA
来源：
DRUGS | 2013年 / 73卷 / 12期
基金：
美国国家卫生研究院;
关键词：
MULTIPLE SYSTEM ATROPHY; SHY-DRAGER SYNDROME; NOREPINEPHRINE TRANSPORTER BLOCKADE; L-DIHYDROXYPHENYLSERINE DROXIDOPA; DOPAMINE-BETA-HYDROXYLASE; SUDDEN CARDIAC DEATH; PARKINSONS-DISEASE; WATER DRINKING; HEAD-UP; POSTURAL HYPOTENSION;
D O I：
10.1007/s40265-013-0097-0
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The maintenance of blood pressure in the upright position requires intact autonomic cardiovascular reflexes. Diseases that affect the sympathetic innervation of the cardiovascular system result in a sustained fall in blood pressure upon standing (i.e., neurogenic orthostatic hypotension) that can impair the blood supply to the brain and other organs and cause considerable morbidity and mortality. Here we review treatment options for neurogenic orthostatic hypotension and include an algorithm for its management that emphasizes the importance of non-pharmacologic measures and provides guidance on pharmacologic treatment options.
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页码：1267 / 1279
页数：13
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