Spatiotemporal Changes of Calcitonin Gene-Related Peptide Innervation in Spinal Fusion

被引：3

作者：

Zhou, Xiao-Yi ^{[1
]}

Xu, Xi-Ming ^{[2
]}

Wu, Sui-Yi ^{[3
]}

Wang, Fei ^{[1
]}

Yang, Yi-Lin ^{[1
]}

Li, Ming ^{[1
]}

Wei, Xian-Zhao ^{[1
]}

机构：

[1] Second Mil Med Univ, Changhai Hosp, Dept Orthopaed Surg, Shanghai, Peoples R China

[2] Second Mil Med Univ, Changzheng Hosp, Dept Orthopaed Surg, Shanghai, Peoples R China

[3] Second Mil Med Univ, Fac Naval Med, Shanghai, Peoples R China

来源：

BIOMED RESEARCH INTERNATIONAL | 2016年 / 2016卷

基金：

上海市自然科学基金; 中国国家自然科学基金;

关键词：

BONE TISSUE; REPAIR; INVOLVEMENT; ULTRASOUND; CELLS; CGRP;

D O I：

10.1155/2016/5872860

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Few studies have investigated the role calcitonin gene-related peptide (CGRP) plays in the process of spinal fusion. The aim of the present study is to observe the temporal and spatial changes of CGRP induced by experimental fusion surgery in rats and elucidate the role of CGRP in spinal fusion. Male Sprague-Dawley rats were used in the study and the specimens were collected on the 7th, 14th, 21st, and 28th day, respectively. Then, histological and immunohistochemical analysis were applied to evaluate the fusion mass and spatiotemporal changes of CGRP chronologically. The results demonstrated that density of CGRP reached peak on the 21st day after surgery and most of the CGRP expression located surrounding the interface of allograft and fibrous tissue where the cells differentiate into osteoblasts, indicating that CGRP might be involved in the process of bone formation and absorption.

引用

页数：5

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