Zinc Depletion Activates the Endoplasmic Reticulum-Stress Sensor Ire1 via Pleiotropic Mechanisms

被引：19

作者：

Thanh Sy Le Nguyen ^{[1
]}

Kohno, Kenji ^{[1
]}

Kimata, Yukio ^{[1
]}

机构：

[1] Nara Inst Sci & Technol, Grad Sch Biol Sci, Nara 6300192, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2013年 / 77卷 / 06期

基金：

日本学术振兴会;

关键词：

stress response; Saccharomyces cerevisiae; organelle; trace element; mineral; UNFOLDED PROTEINS;

D O I：

10.1271/bbb.130130

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Although zinc deficiency evokes the endoplasmic reticulum (ER)-stress response, the activating mechanism remains obscure. Here we show that in yeast cells, the ER-stress sensor Ire1 was activated upon zinc deficiency. ER-stressing stimuli activating Ire1 are known to include ER accumulation of unfolded proteins and membrane-lipid aberrancy. According to the findings presented here, zinc deficiency causes both types of abnormality.

引用

页码：1337 / 1339

页数：3

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