Preclinical activity of MCLA-128, an ADCC enhanced bispecific IgG1 antibody targeting the HER2: HER3 heterodimer

被引:8
|
作者
Geuijen, Cecile
Rovers, Eric
Nijhuis, Roy
den Blanken-Smit, Renate
Visser, Therese
Bartelink, Willem
Kramer, Arjen
Zondag-van der Zande, Vanessa
Clements, Carina
Kaldenberg, Linda
Nieuwenhuizen, Nellie
van Loo, Pieter Fokko
Roovers, Rob
Gallenne, Tristan
Price, Leo
Shamsili, Setareh Van Driel
Bakker, Lex
Logtenberg, Ton
de Kruif, John
Throsby, Mark
机构
[1] Merus, Utrecht, Netherlands
[2] OcellO, Leiden, Netherlands
关键词
D O I
10.1200/jco.2014.32.15_suppl.560
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
560
引用
收藏
页数:1
相关论文
共 50 条
  • [41] Pan-HER, an antibody mixture simultaneously targeting EGFR, HER2, and HER3, is highly effective in triple negative breast cancer patient-derived xenografts
    Rosato, Roberto R.
    Choi, Don S.
    Qian, Wei
    Chen, Wen
    Lantto, Johan
    Horak, Ivan D.
    Kragh, Michael
    Chang, Jenny C.
    CANCER RESEARCH, 2019, 79 (13)
  • [42] Targeting EGFR/HER2/HER3 with a Three-in-One Aptamer-siRNA Chimera Confers Superior Activity against HER2+ Breast Cancer
    Yu, Xiaolin
    Ghamande, Sharad
    Liu, Haitao
    Xue, Lu
    Zhao, Shuhua
    Tan, Wenxi
    Zhao, Lijing
    Tang, Shou-Ching
    Wu, Daqing
    Korkaya, Hasan
    Maihle, Nita J.
    Liu, Hong Yan
    MOLECULAR THERAPY-NUCLEIC ACIDS, 2018, 10 : 317 - 330
  • [43] Anti-tumor activity in preclinical models utilizing a conditional bispecific redirected activation molecule (COBRA) targeting Her2
    Stringer, Bradley
    Chouitar, Johara
    Cerbone, Jacqualine
    Fortin, Sarah
    Ainbinder, Alina
    Kysilovsky, Cassie
    Scott, Brittany
    Banerjee, Antara
    CANCER RESEARCH, 2024, 84 (07)
  • [44] D3L-001, a novel bispecific antibody targeting HER2 and CD47, demonstrates potent preclinical efficacy in solid tumors
    Rui, Haopeng
    Yang, Xiaofeng
    Chen, Jiahao
    Wang, Jia
    Zheng, Zhiqiang
    Chen, Zhiqiang
    Lu, Jingtao
    Wu, Peggy
    Chen, Janet
    Wang, Allison
    Chen, George
    CANCER RESEARCH, 2023, 83 (07)
  • [45] BSI-730, a bispecific antibody targeting HER2 and PD-L1 for the development of a first-in-class bispecific ADC
    Hao, Xiaoyao
    Li, Hongyan
    Liu, Xiaodong F.
    Liu, Jinyu
    Dai, Wenwen
    Pan, Ying
    Hu, Hui-Han
    Li, Jun
    Xia, Shukai
    Lyu, Qun
    Davis, Hugh M.
    Chen, Mingjiu
    Peng, Zeyu
    CANCER RESEARCH, 2024, 84 (06)
  • [46] AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor (EGFR), HER2, and HER3: preclinical activity in HER2 non-amplified inflammatory breast cancer models
    Zhaomei Mu
    Teresa Klinowska
    Xiaoshen Dong
    Emily Foster
    Chris Womack
    Sandra V Fernandez
    Massimo Cristofanilli
    Journal of Experimental & Clinical Cancer Research, 33
  • [47] AZD8931, an equipotent, reversible inhibitor of signaling by epidermal growth factor receptor (EGFR), HER2, and HER3: preclinical activity in HER2 non-amplified inflammatory breast cancer models
    Mu, Zhaomei
    Klinowska, Teresa
    Dong, Xiaoshen
    Foster, Emily
    Womack, Chris
    Fernandez, Sandra V.
    Cristofanilli, Massimo
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2014, 33
  • [48] Pan-HERAn antibody mixture targeting EGFR, HER2 and HER3 abrogates preformed and ligand-induced EGFR homo- and heterodimers
    Ellebaek, Sofie
    Brix, Susanne
    Grandal, Michael
    Lantto, Johan
    Horak, Ivan D.
    Kragh, Michael
    Poulsen, Thomas Tuxen
    INTERNATIONAL JOURNAL OF CANCER, 2016, 139 (09) : 2095 - 2105
  • [49] HER2/PD1 bispecific antibody in IgG4 subclass with superior anti-tumour activities
    Chu, Wendi
    Xu, Hui
    Wang, Yanfei
    Xie, Yongle
    Chen, Yi-Li
    Tan, Xiaorong
    Huang, Chenghao
    Wang, Guifeng
    Wang, Qi
    Luo, Wenxin
    Xia, Ningshao
    Geng, Meiyu
    Xie, Zuoquan
    Wang, Chunhe
    CLINICAL AND TRANSLATIONAL MEDICINE, 2022, 12 (04):
  • [50] Preclinical development of a bispecific antibody-trap selectively targeting CD47 and HER2 for the treatment of breast as well as gastric cancer
    Tian, Wenzhi
    Li, Song
    Chen, Dianze
    Liu, Dandan
    Guo, Huiqin
    Yang, Chunmei
    Zhang, Li
    Zhang, Wei
    Tu, Xiaoping
    Peng, Liang
    Zhao, Gui
    Zhang, Ruliang
    Zhang, Fan
    CANCER RESEARCH, 2022, 82 (12)