Reduced biocide susceptibility in Candida albicans biofilms

被引：54
|
作者：
Nett, Jeniel E. [2 ]
Guite, Kristie M. [2 ]
Ringeisen, Alex [3 ]
Holoyda, Kathleen A. [3 ]
Andes, David R. [1 ,2 ,3 ]
机构：
[1] Univ Wisconsin, Ctr Clin Sci, Dept Cellular & Mol Biol, Madison, WI 53792 USA
[2] Univ Wisconsin, Dept Med, Madison, WI 53792 USA
[3] Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53792 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 09期
关键词：
D O I：
10.1128/AAC.01656-07
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Candida biofilm formation is common during infection and environmental growth. We tested the impacts of three biocides (ethanol [EtOH], H2O2, and sodium dodecyl sulfate) on Candida albicans, C. parapsilosis, and C. glabrata biofilms. Higher concentrations of the biocides were required for efficacy against biofilms than for efficacy against planktonic controls. A combination study with two biocides (EtOH and H2O2) and fluconazole demonstrated that the combination had enhanced efficacy.
引用
收藏
页码：3411 / 3413
页数：3
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