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Reduced biocide susceptibility in Candida albicans biofilms
被引:54
|作者:
Nett, Jeniel E.
[2
]
Guite, Kristie M.
[2
]
Ringeisen, Alex
[3
]
Holoyda, Kathleen A.
[3
]
Andes, David R.
[1
,2
,3
]
机构:
[1] Univ Wisconsin, Ctr Clin Sci, Dept Cellular & Mol Biol, Madison, WI 53792 USA
[2] Univ Wisconsin, Dept Med, Madison, WI 53792 USA
[3] Univ Wisconsin, Dept Med Microbiol & Immunol, Madison, WI 53792 USA
关键词:
D O I:
10.1128/AAC.01656-07
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Candida biofilm formation is common during infection and environmental growth. We tested the impacts of three biocides (ethanol [EtOH], H2O2, and sodium dodecyl sulfate) on Candida albicans, C. parapsilosis, and C. glabrata biofilms. Higher concentrations of the biocides were required for efficacy against biofilms than for efficacy against planktonic controls. A combination study with two biocides (EtOH and H2O2) and fluconazole demonstrated that the combination had enhanced efficacy.
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页码:3411 / 3413
页数:3
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