Recent Development of Magnetic Particle Imaging Tracers

Magnetic particle imaging(MPI) is a tracer method based on functional and tomography imaging techniques to detect the spatial distribution of magnetic nanoparticles(MNPs),the contrast of positive signal,low background, infinite tissue penetration depth, non-invasive imaging as well as the advantages of no ionizing radiation,which is a promising biomedical imaging technology in recent years. The MPI signal is generated by switching the magnetic spin vector of MNPs at field-free points(FFP). The imaging sensitivity and spatial resolution of MPI are highly dependent on the magnetic properties of MNPs themselves as MPI tracers ,so the current research is mainly focused on the design and synthesis of MNPs. This review focuses on the latest research progress of MPI tracers,and summarizes the types,synthesis methods,properties and biomedical applications of MNPs that can be used as MPI tracers,in order to provide reference for the future development of MPI.