Pro-Antimicrobial Networks via Degradable Acetals (PANDAs) Using Thiol-Ene Photopolymerization

被引：23

作者：

Amato, Dahlia N. ^{[1
]}

Amato, Douglas V. ^{[1
]}

Mavrodi, Olga V. ^{[2
]}

Martin, William B. ^{[1
]}

Swilley, Sarah N. ^{[1
]}

Parsons, Keith H. ^{[1
]}

Mavrodi, Dmitri V. ^{[2
]}

Patton, Derek L. ^{[1
]}

机构：

[1] Univ Southern Mississippi, Sch Polymers & High Performance Mat, Hattiesburg, MS 39406 USA

[2] Univ Southern Mississippi, Dept Biol Sci, Hattiesburg, MS 39406 USA

来源：

ACS MACRO LETTERS | 2017年 / 6卷 / 02期

基金：

美国国家科学基金会;

关键词：

CROSS-LINKED POLYESTERS; CONTROLLED-RELEASE; ANTIBACTERIAL ACTIVITIES; POLYMERIC PRODRUG; EXTENDED-RELEASE; SALICYLIC-ACID; ESSENTIAL OILS; IN-VITRO; ANTIOXIDANT; BEHAVIOR;

D O I：

10.1021/acsmacrolett.7b00009

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

We describe the synthesis of pro-antimicrobial networks via degradable acetals (PANDAs) as a new paradigm for sequestration and triggered release of volatile, bioactive aldehydes. PANDAS derived from diallyl p-chlorobenzaldehyde acetal degrade and release p-chlorobenzaldehyde as an antibacterial and antifungal agent under mild conditions (pH 7.4/high humidity). We show that PANDAS enable facile access to materials with tunable release profiles, potent antimicrobial activity without triggering antimicrobial resistance, and minimal cytotoxicity.

引用

页码：171 / 175

页数：5

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