Transition-metal free umpolung carbon-nitrogen versus carbon-chlorine bond formation

被引：6

作者：

Sirois, John J. ^{[1
]}

DeBoef, Brenton ^{[1
]}

机构：

[1] Univ Rhode Isl, Dept Chem, Kingston, RI 02881 USA

来源：

TETRAHEDRON LETTERS | 2015年 / 56卷 / 41期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

Metal-free; Grignard reagent; Chloroamine; Amination; CATALYZED ELECTROPHILIC AMINATION; ARYL CHLORIDES; ARYLATION; AMINES;

D O I：

10.1016/j.tetlet.2015.08.053

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The formation of carbon-nitrogen (C-N) bonds via an umpolung substitution reaction has been achieved at -78 degrees C without the need for catalysts, ligands, or additives. The scope is limited to aryl Grignard reagents with N-chloroamines. The findings in this manuscript serve as a reference point for all C-N bond formations involving N-chloroamines and organometallic reagents. Knowing the yields of uncatalyzed reactions will be useful when determining the success of future catalytic methods. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：5610 / 5612

页数：3

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