OREXIN SYSTEM: NETWORK MULTI-TASKING

被引：27

作者：

Sperandeo, Raffaele ^{[1
,2
]}

Maldonato, Mauro N. ^{[3
]}

Messina, Antonietta ^{[3
]}

Cozzolino, Pasquale ^{[4
]}

Monda, Marcellino ^{[3
]}

Cerroni, Francesco ^{[5
]}

Romano, Palmira ^{[5
]}

Salerno, Margherita ^{[7
]}

Maltese, Agata ^{[7
]}

Roccella, Michele ^{[7
]}

Parisi, Lucia ^{[7
]}

Tripi, Gabriele ^{[7
]}

Moscatelli, Fiorenzo ^{[8
]}

Sessa, Francesco ^{[8
]}

Salerno, Monica ^{[8
]}

Cibelli, Giuseppe ^{[8
]}

Messina, Giovanni ^{[8
]}

Monda, Vincenzo ^{[9
,10
]}

Chieffi, Sergio ^{[9
,10
]}

Villano, Ines ^{[9
,10
]}

Monda, Emanuele ^{[9
,10
]}

Ruberto, Maria ^{[11
]}

Marsala, Gabriella ^{[12
]}

Marotta, Rosa R. ^{[6
]}

Velenzano, Anna ^{[8
]}

机构：

[1] Univ Campania, Dept Expt Med, Sect Human Physiol, Naples, Italy

[2] Univ Campania, Unit Dietet & Sport Med, Naples, Italy

[3] Univ Basilicata, Dept Human Sci, Potenza, Italy

[4] SiPGI Postgrad Sch Integrated Gestalt Psychothera, DM 12 10 2007, Naples, Italy

[5] Univ Campania Luigi Vanvitelli, Dept Mental Hlth Phys & Prevent Med, Clin Child & Adolescent Neuropsychiat, Naples, Italy

[6] Magna Graecia Univ Catanzaro, Dept Hlth Sci, Catanzaro, Italy

[7] Univ Palermo, Dept Psychol & Pedag Sci, Child Neuropsychiat, Palermo, Italy

[8] Univ Foggia, Dept Clin & Expt Med, Foggia, Italy

[9] Univ Campania Luigi Vanvitelli, Dept Expt Med, Sect Human Physiol, Naples, Italy

[10] Univ Campania Luigi Vanvitelli, Unit Dietet & Sports Med, Naples, Italy

[11] Ctr CRD, Naples, Italy

[12] Azienda Osped Univ, Struttura Complessa Farm, Foggia, Italy

来源：

ACTA MEDICA MEDITERRANEA | 2018年 / 34卷 / 02期

关键词：

Orexin; Obesity; emotional stress; narcolepsy; RESTING ENERGY-EXPENDITURE; SLEEP-APNEA SYNDROME; HYPOCRETIN/OREXIN NEURONS; CHILDHOOD MIGRAINE; RAT-BRAIN; CHILDREN; RECEPTOR; EXPRESSION; NARCOLEPSY; AURA;

D O I：

10.19193/0393-6384_2018_2_55

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Orexin system regulates sleep/wake states and its deficiency result in narcolepsy thus indicating the crucial role of orexins in maintaining wakefulness. There are two types of orexin peptides: the orexin-A (OXA or hypocretin 1) and orexin-B (OXB or hypocretin 2). The Majority of the central nervous system orexin peptides are synthesized in neurons located in the lateral and back hypothalamus and send projections throughout the brain regions Orexin neurons are "multi-tasking" hence regulating also energy homeostasis, reward systems and feeding behaviour through connection with hypothalamic nuclei and through responsiveness to leptine and glucose. It has recently been found a connection with lymbic system suggesting a further possible role of orexins in regulating emotions. All the studies conducted confirm that orexin system regulates vigilance states, energy homeostasis, reward system, and emotions. These crucial role might be the target to develope treatments of narcolepsy, obesity, emotional stress, and drug addiction.

引用

页码：349 / 356

页数：8

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