Identification of the GABA(A) receptor alpha-subunit mRNA in rat intestine

被引：17
|
作者：
Zeiter, DK [1 ]
Li, XS [1 ]
Broussard, DL [1 ]
机构：
[1] CHILDRENS HOSP,DIV GASTROENTEROL & NUTR,PHILADELPHIA,PA 19104
来源：
MOLECULAR BRAIN RESEARCH | 1996年 / 39卷 / 1-2期
关键词：
GABA(A) receptor; enteric nervous system; hybridization; in-situ; reverse transcription-polymerase chain reaction; gamma-aminobutyric acid; myenteric plexus; rat;
D O I：
10.1016/0169-328X(96)00077-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We investigated the expression of gamma-aminobutyric acid type A (GABA(A)) receptor alpha 1-, alpha 2- and alpha 3-subunit mRNAs in the rat intestine using reverse transcription and polymerase chain reaction. alpha 1- and alpha 3-, but not alpha 2-, subunit mRNAs were amplified from the proximal intestine, ileum, and colon. In-situ hybridization studies demonstrated the expression of alpha 1-subunit mRNA by myenteric neurons. GABA may be active via the GABA(A) receptor in the enteric nervous system.
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页码：241 / 244
页数：4
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