Genetic Susceptibility of the Host in Virus-Induced Diabetes

被引：17

作者：

Mine, Keiichiro ^{[1
,2
]}

Yoshikai, Yasunobu ^{[2
]}

Takahashi, Hirokazu ^{[1
,3
]}

Mori, Hitoe ^{[1
]}

Anzai, Keizo ^{[1
]}

Nagafuchi, Seiho ^{[1
]}

机构：

[1] Saga Univ, Fac Med, Div Endocrinol & Metab, 5-1-1 Nabeshima, Saga 8498501, Japan

[2] Kyushu Univ, Div Host Def, Med Inst Bioregulat, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan

[3] Saga Univ, Saga Univ Hosp, Liver Ctr, 5-1-1 Nabeshima, Saga 8498501, Japan

来源：

MICROORGANISMS | 2020年 / 8卷 / 08期

关键词：

diabetes; virus; susceptibility genes; PANCREATIC BETA-CELLS; KILHAM RAT VIRUS; DIABETOGENIC VARIANT; VIRAL-INFECTIONS; CANDIDATE GENE; NOD MICE; B-CELLS; TYPE-1; MELLITUS; EXPRESSION;

D O I：

10.3390/microorganisms8081133

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID). Host background, in terms of whether the host is prone to autoimmunity, should also be considered when analyzing the role of target genes in VID. In this review, we describe the genetic susceptibility of the host based on studies in humans and VID animal models. Understanding the host genetic factors should contribute not only to revealing the mechanisms of VID development, but also in taking measures to prevent VID.

引用

页码：1 / 20

页数：20

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