Genotoxicity and oxidative stress in gasoline station attendants

被引：38

作者：

Moro, Angela M. ^{[1
,2
]}

Charao, Mariele F. ^{[1
,2
]}

Brucker, Natalia ^{[1
,2
]}

Durgante, Juliano ^{[1
]}

Baierle, Marilia ^{[1
,2
]}

Bubols, Guilherme ^{[1
,2
]}

Goethel, Gabriela ^{[1
,2
]}

Fracasso, Rafael ^{[1
,2
]}

Nascimento, Sabrina ^{[1
,2
]}

Bulcao, Rachel ^{[1
,2
]}

Gauer, Bruna ^{[1
]}

Barth, Anelise ^{[1
,2
]}

Bochi, Guilherme ^{[3
]}

Moresco, Rafael ^{[3
]}

Gioda, Adriana ^{[4
]}

Salvador, Mirian ^{[5
]}

Farsky, Sandra ^{[6
]}

Garcia, Solange C. ^{[1
,2
]}

机构：

[1] Univ Fed Rio Grande do Sul, Lab Toxicol LATOX, Dept Anal, Fac Pharm, Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Postgrad Program Pharmaceut Sci, Porto Alegre, RS, Brazil

[3] Univ Fed Santa Maria, Lab Clin Biochem, Dept Clin & Toxicol Anal, BR-97119900 Santa Maria, RS, Brazil

[4] Univ Fed Rio de Janeiro, Dept Chem Pontif Catholic, Rio De Janeiro, Brazil

[5] Univ Caxias do Sul, Inst Biotechnol, Lab Oxidat Stress & Antioxidants, BR-95070560 Caxias Do Sul, RS, Brazil

[6] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Clin & Toxicol Anal, BR-05508 Sao Paulo, Brazil

来源：

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS | 2013年 / 754卷 / 1-2期

关键词：

Low benzene exposure; Genotoxicity; Protein carbonyl; 3-Nitrotyrosine; Vitamin C; GLUTATHIONE S-TRANSFERASES; DNA-DAMAGE; BENZENE EXPOSURE; SUPEROXIDE-DISMUTASE; GENETIC POLYMORPHISMS; VITAMIN-C; IN-VITRO; ACID; QUANTIFICATION; WORKERS;

D O I：

10.1016/j.mrgentox.2013.04.008

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We evaluated genotoxic effects of exposure to low levels of benzene, a class I human carcinogen, among gasoline station attendants (GSA). Oxidative stress and the protective effects of antioxidants on DNA damage were also analyzed. Although exposures were below ACGIH (American Conference of Governmental Industrial Hygienists) limits, the GSA group presented higher DNA damage indices and micronucleus frequencies, increased oxidative protein damage, and decreased antioxidant capacity relative to the control group. Duration of benzene exposure was correlated with DNA and protein damage. The biomarkers evaluated in this work may provide early signals of damage in subjects occupationally exposed to benzene. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：63 / 70

页数：8

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