HLA-E and immunobiology of pregnancy

被引：49
|
作者：
Tripathi, P
Naik, S
Agrawal, S
机构：
[1] Sanjay Gandhi Postgrad Inst Med Sci, Dept Med Genet, Lucknow 226014, Uttar Pradesh, India
[2] Sanjay Gandhi Postgrad Inst Med Sci, Dept Immunol, Lucknow 226014, Uttar Pradesh, India
来源：
TISSUE ANTIGENS | 2006年 / 67卷 / 03期
关键词：
amplification refractory mutation system; HLA-E; killer inhibitory receptor; polymorphism; recurrent spontaneous abortion;
D O I：
10.1111/j.1399-0039.2005.00550.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Recently, it has been suggested that non-classical antigens such as human leukocyte antigen (HLA)-G and HLA-E may interact with KIR receptors of NK cells which results into downregulation of immune response and helps in the maintenance of pregnancy. In the present study, we have investigated HLA-E polymorphism in normal fertile women and recurrent spontaneous aborters to assess the effect of HLA-E alleles on the success of pregnancy. Allele E*0101 was found to be significantly higher in patients with recurrent spontaneous abortion (chi(2) = 4.097 and P = 0.0430). Differential expression, peptide affinity, and stability of E*0101 may be one of the reasons.
引用
收藏
页码：207 / 213
页数：7
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