Phylogenetic perspectives in innate immunity

被引：2051

作者：

Hoffmann, JA ^{[1
]}

Kafatos, FC

Janeway, CA

Ezekowitz, RAB

机构：

[1] CNRS, Inst Mol & Cellular Biol, F-67084 Strasbourg, France

[2] European Mol Biol Lab, D-69012 Heidelberg, Germany

[3] Yale Univ, Immunobiol Sect, New Haven, CT 06520 USA

[4] Massachusetts Gen Hosp, Dept Pediat, Boston, MA 02114 USA

来源：

SCIENCE | 1999年 / 284卷 / 5418期

关键词：

D O I：

10.1126/science.284.5418.1313

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The concept of innate immunity refers to the first-line host defense that serves to Limit infection in the early hours after exposure to microorganisms, Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity;in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.

引用

页码：1313 / 1318

页数：6

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