A receptor for green tea polyphenol EGCG

被引：565
|
作者：
Tachibana, H [1 ]
Koga, K [1 ]
Fujimura, Y [1 ]
Yamada, K [1 ]
机构：
[1] Kyushu Univ, Fac Agr, Dept Biosci & Biotechnol, Fukuoka 8128581, Japan
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2004年 / 11卷 / 04期
关键词：
D O I：
10.1038/nsmb743
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The major polyphenol in green tea, (-) - epigallocatechin-3-gallate (EGCG), has been shown to prevent carcinogenesis. We have identified a receptor that mediates the anticancer activity of EGCG. Expression of the metastasis-associated 67-kDa laminin receptor confers EGCG responsiveness to cancer cells at physiologically relevant concentrations. Experiments using surface plasmon resonance demonstrate binding of EGCG to the 67-kDa laminin receptor with a nanomolar K-d value.
引用
收藏
页码：380 / 381
页数：2
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