The Long Pentraxin PTX3 as a Link Between Innate Immunity, Tissue Remodeling, and Cancer

被引：104
|
作者：
Doni, Andrea [1 ]
Stravalaci, Matteo [2 ]
Inforzato, Antonio [1 ,2 ]
Magrini, Elena [1 ]
Mantovani, Alberto [1 ,2 ,3 ]
Garlanda, Cecilia [1 ,2 ]
Bottazzi, Barbara [1 ]
机构：
[1] Humanitas Clin & Res Inst IRCCS, Milan, Italy
[2] Humanitas Univ, Dept Biomed Sci, Milan, Italy
[3] Queen Mary Univ London, William Harvey Res Inst, London, England
来源：
FRONTIERS IN IMMUNOLOGY | 2019年 / 10卷
基金：
欧洲研究理事会;
关键词：
pentraxins; PTX3; inflammation; tissue remodeling; wound healing; C-REACTIVE PROTEIN; RECOGNITION RECEPTOR PTX3; PLASMA-LEVELS; HEPATOCELLULAR-CARCINOMA; CRYSTAL-STRUCTURE; EPITHELIAL-CELLS; POOR-PROGNOSIS; KEY COMPONENT; FACTOR-H; INFLAMMATION;
D O I：
10.3389/fimmu.2019.00712
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The innate immune system comprises a cellular and a humoral arm. Humoral pattern recognition molecules include complement components, collectins, ficolins, and pentraxins. These molecules are involved in innate immune responses by recognizing microbial moieties and damaged tissues, activating complement, exerting opsonic activity and facilitating phagocytosis, and regulating inflammation. The long pentraxin PTX3 is a prototypic humoral pattern recognition molecule that, in addition to providing defense against infectious agents, plays several functions in tissue repair and regulation of cancer-related inflammation. Characterization of the PTX3 molecular structure and biochemical properties, and insights into its interactome and multiple roles in tissue damage and remodeling support the view that microbial and matrix recognition are evolutionarily conserved functions of humoral innate immunity molecules.
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页数：13
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