Synthesis and Biological Activity of 3,4-Diaryl-5-[4-(acetylsulfamoyl)phenyl]-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-ones and Their Sodium Salts

被引：2
|
作者：
Bobrovskaya, O. V. [1 ]
Gein, V. L. [1 ]
Seliverstov, G. V. [1 ]
Chashchina, S. V. [1 ]
Dmitriev, M. V. [2 ]
机构：
[1] Perm State Pharmaceut Acad, Ul Polevaya 2, Perm 614990, Russia
[2] Perm State Natl Res Univ, Ul Bukireva 15, Perm 614990, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2017年 / 87卷 / 12期
关键词：
pyrrolo[3,4-c]pyrazol-6-ones; pyrrolo[3,4-c]pyrazol-6-one sodium salts; analgesic activity; anti-inflammatory activity; acute toxicity; ANTIBACTERIAL ACTIVITY;
D O I：
10.1134/S1070363217120040
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
3,4-Diaryl-5-[4-(acetylsulfamoyl)phenyl]-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-ones were synthesized be reaction of 5-aryl-4-aroyl-1-[4-(acetylsulfamoyl)phenyl]-3-hydroxy-1H-pyrrole-2(5H)-ones with hydrazine hydrate in glacial acetic acid, and their sodium salts were obtained by treatment with sodium methoxide in methanol-DMF (1: 1). Analgesic and anti-inflammatory activity and acute toxicity of the synthesized compounds were studied.
引用
收藏
页码：2776 / 2782
页数：7
相关论文
共 50 条
  • [21] SYNTHESIS AND TRAPPING OF 4H-THIENO[3,4-C]PYRROLE AND 5H-THIENO[3,4-C]PYRROLE
    SHA, CK
    TSOU, CP
    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1994, (21): : 3065 - 3070
  • [22] 4-(3,4-Dihydroxybenzylideneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one
    Sun, Yu-Xi
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2006, 62 : O5860 - O5861
  • [23] BIOLOGICAL-ACTIVITY OF 4-METHYL-5-PHENYL-6-KETO-[4H]-PYRAZOLO[3,4-D]PYRAZOL
    VORONIN, VG
    SHRAMOVA, ZI
    SKACHILOVA, SY
    KULIKOVA, LD
    ERMAKOV, AI
    ZAKS, AS
    SUSLINA, ML
    KHIMIKO-FARMATSEVTICHESKII ZHURNAL, 1985, 19 (10): : 1208 - 1214
  • [24] 4-[(3,4-Dimethoxybenzylidene)amino]-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one
    Asiri, Abdullah M.
    Khan, Salman A.
    Tan, Kong Wai
    Ng, Seik Weng
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O1732 - U816
  • [25] 4-DIAZOMETHYLCOUMARINS AS STABLE DIAZOALKANES - THEIR FACILE ISOMERIZATION INTO BENZOPYRANO[3,4-C]PYRAZOL-4(3H)-ONES
    ITO, K
    NAGASAWA, K
    MARUYAMA, J
    HETEROCYCLES, 1984, 21 : 530 - 530
  • [26] Biological activities of 4-(substitued phenyl)-5-(2,4-dinitrophenyl)-3-methyl-1,3a,4,5-tetrahydropyrazolo-[3,4-c]pyrazole
    Bhaskar, V. H.
    More, V. S.
    Kumar, M.
    ASIAN JOURNAL OF CHEMISTRY, 2008, 20 (07) : 5474 - 5482
  • [27] Synthesis and in vitro antibacterial activities of 7-(3-aminopyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)quinolone derivatives
    Guo, Xin
    Li, Yi Liang
    Liu, Yu Fei
    Guo, Hui Yuan
    Wang, Yu Cheng
    CHINESE CHEMICAL LETTERS, 2010, 21 (10) : 1141 - 1144
  • [28] Synthesis and in vitro antibacterial activities of 7-(3-aminopyrrolo[3,4-c]pyrazol-5(2H,4H,6H)-yl)quinolone derivatives
    Xin Guo~(a
    Chinese Chemical Letters, 2010, 21 (10) : 1141 - 1144
  • [29] 4-[(3-Hydroxy-5-phenyl-1H-pyrazol-4-yl)-methyl]-5-phenyl-1H-pyrazol-3(2H)-one
    Baryala, Yamna
    Zerzouf, Abdelfettah
    Essassi, El Mokhtar
    Reuter, Hans
    Eickmeier, Henning
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2007, 63 : O2554 - O2556
  • [30] A FACILE INTRAMOLECULAR CYCLIZATION OF 4-DIAZOMETHYLCOUMARINS - A CONVENIENT ROUTE TO BENZOPYRANO[3,4-C]PYRAZOL-4(3H)-ONES
    ITO, K
    MARUYAMA, J
    HETEROCYCLES, 1984, 22 (05) : 1057 - 1059
12345