Synthesis and Biological Activity of 3,4-Diaryl-5-[4-(acetylsulfamoyl)phenyl]-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-ones and Their Sodium Salts

被引：2
|
作者：
Bobrovskaya, O. V. [1 ]
Gein, V. L. [1 ]
Seliverstov, G. V. [1 ]
Chashchina, S. V. [1 ]
Dmitriev, M. V. [2 ]
机构：
[1] Perm State Pharmaceut Acad, Ul Polevaya 2, Perm 614990, Russia
[2] Perm State Natl Res Univ, Ul Bukireva 15, Perm 614990, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2017年 / 87卷 / 12期
关键词：
pyrrolo[3,4-c]pyrazol-6-ones; pyrrolo[3,4-c]pyrazol-6-one sodium salts; analgesic activity; anti-inflammatory activity; acute toxicity; ANTIBACTERIAL ACTIVITY;
D O I：
10.1134/S1070363217120040
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
3,4-Diaryl-5-[4-(acetylsulfamoyl)phenyl]-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-ones were synthesized be reaction of 5-aryl-4-aroyl-1-[4-(acetylsulfamoyl)phenyl]-3-hydroxy-1H-pyrrole-2(5H)-ones with hydrazine hydrate in glacial acetic acid, and their sodium salts were obtained by treatment with sodium methoxide in methanol-DMF (1: 1). Analgesic and anti-inflammatory activity and acute toxicity of the synthesized compounds were studied.
引用
收藏
页码：2776 / 2782
页数：7
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