The function of ROCO proteins in health and disease

被引：42
|
作者：
Lewis, Patrick A. [1 ,2 ]
机构：
[1] UCL, Dept Mol Neurosci, London WC1N 3BG, England
[2] UCL, Inst Neurol, Reta Lila Weston Labs, London WC1N 3BG, England
来源：
BIOLOGY OF THE CELL | 2009年 / 101卷 / 03期
关键词：
cancer; GTPase; kinase; LRRK2; Parkinson's disease; ROCO; FAMILIAL PARKINSONS-DISEASE; KINASE-ACTIVITY; DAP-KINASE; GTP-BINDING; LEUCINE-RICH-REPEAT-KINASE-2; LRRK2; NEURONAL TOXICITY; LIPID RAFTS; GENE LRRK2; CELL-DEATH; MUTATIONS;
D O I：
10.1042/BC20080053
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The ROCO family of multidomain proteins extends across the eukaryotes, and has been implicated in numerous cellular processes. Following the description of mutations causing PD (Parkinson's disease) in a human representative of the ROCO family, LRRK2 (leucine-rich repeat kinase 2), a great deal of research has been carried out into these proteins. This review examines the published data regarding the roles the ROCO proteins are thought to play in cell processes, and how the structure and domain organization of these proteins relates to their function.
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页码：183 / 191
页数：9
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