Influenza A Virus Entry Inhibitors Targeting the Hemagglutinin

被引：98

作者：

Yang, Jie ^{[1
]}

Li, Minmin ^{[2
]}

Shen, Xintian ^{[1
]}

Liu, Shuwen ^{[1
]}

机构：

[1] Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China

[2] Jinan Univ, Affiliated Hosp 1, Dept Clin Lab, Guangzhou 510630, Guangdong, Peoples R China

来源：

VIRUSES-BASEL | 2013年 / 5卷 / 01期

关键词：

influenza A virus; hemagglutinin; viral entry; antiviral drugs; MEDIATED MEMBRANE-FUSION; CONFORMATIONAL-CHANGE; POTENT INHIBITORS; VIRAL ATTACHMENT; RECEPTOR-BINDING; CLEAVAGE SITE; IN-VIVO; H5N1; IDENTIFICATION; GLYCOSYLATION;

D O I：

10.3390/v5010352

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Influenza A virus (IAV) has caused seasonal influenza epidemics and influenza pandemics, which resulted in serious threat to public health and socioeconomic impacts. Until now, only 5 drugs belong to two categories are used for prophylaxis and treatment of IAV infection. Hemagglutinin (HA), the envelope glycoprotein of IAV, plays a critical role in viral binding, fusion and entry. Therefore, HA is an attractive target for developing anti-IAV drugs to block the entry step of IAV infection. Here we reviewed the recent progress in the study of conformational changes of HA during viral fusion process and the development of HA-based IAV entry inhibitors, which may provide a new choice for controlling future influenza pandemics.

引用

页码：352 / 373

页数：22

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