Transporter-Targeted Nano-Sized Vehicles for Enhanced and Site-Specific Drug Delivery

被引:22
|
作者
Kou, Longfa [1 ,2 ,3 ]
Yao, Qing [3 ,4 ]
Zhang, Hailin [2 ,3 ,5 ]
Chu, Maoping [2 ,3 ,6 ]
Bhutia, Yangzom D. [7 ]
Chen, Ruijie [1 ,2 ,3 ]
Ganapathy, Vadivel [1 ,2 ,3 ,7 ]
机构
[1] Wenzhou Med Univ, Affiliated Hosp 2, Dept Pharm, Wenzhou 325027, Zhejiang, Peoples R China
[2] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Zhejiang, Peoples R China
[3] Wenzhou Municipal Key Lab Pediat Pharm, Wenzhou 325027, Zhejiang, Peoples R China
[4] Wenzhou Med Univ, Dept Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China
[5] Wenzhou Med Univ, Affiliated Hosp 2, Dept Childrens Respirat Dis, Wenzhou 325027, Zhejiang, Peoples R China
[6] Wenzhou Med Univ, Affiliated Hosp 2, Pediat Res Inst, Wenzhou 325027, Zhejiang, Peoples R China
[7] Texas Tech Univ, Hlth Sci Ctr, Dept Cell Biol & Biochem, Lubbock, TX 79430 USA
基金
中国国家自然科学基金;
关键词
plasma membrane transporters; nano-drug delivery systems; targeted drug delivery; oral absorption; site-specific drug delivery; POLY(ETHYLENE GLYCOL)-CO-POLY(TRIMETHYLENE CARBONATE); MOLECULAR-WEIGHT HEPARIN; BLOOD-BRAIN-BARRIER; ORAL DELIVERY; L-CARNITINE; DEOXYCHOLIC-ACID; MODIFIED NANOPARTICLES; GLUCOSE TRANSPORTERS; PEPTIDE TRANSPORTERS; CANCER-CELLS;
D O I
10.3390/cancers12102837
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Simple Summary Nano-drug delivery systems serve as Trojan horses to carry therapeutic drugs as cargos and deliver them to target cells. The specificity of these delivery vehicles to a particular cell type can be improved if the surface of the vehicles is chemically modified in such a manner that they are recognized and attracted to the target cell. This can be accomplished if the target cell selectively expresses a receptor or transporter and the surface of the drug-delivery vehicles is conjugated with the receptor agonist or the transporter substrate. In this review, we detail published literature on the successful exploitation of plasma membrane transporters for this purpose. In particular, this review emphasizes the delivery of chemotherapeutic drugs to cancer cells by targeting the nano-delivery systems specifically to certain transporters that are selectively upregulated in cancer cells. Nano-devices are recognized as increasingly attractive to deliver therapeutics to target cells. The specificity of this approach can be improved by modifying the surface of the delivery vehicles such that they are recognized by the target cells. In the past, cell-surface receptors were exploited for this purpose, but plasma membrane transporters also hold similar potential. Selective transporters are often highly expressed in biological barriers (e.g., intestinal barrier, blood-brain barrier, and blood-retinal barrier) in a site-specific manner, and play a key role in the vectorial transfer of nutrients. Similarly, selective transporters are also overexpressed in the plasma membrane of specific cell types under pathological states to meet the biological needs demanded by such conditions. Nano-drug delivery systems could be strategically modified to make them recognizable by these transporters to enhance the transfer of drugs across the biological barriers or to selectively expose specific cell types to therapeutic drugs. Here, we provide a comprehensive review and detailed evaluation of the recent advances in the field of transporter-targeted nano-drug delivery systems. We specifically focus on areas related to intestinal absorption, transfer across blood-brain barrier, tumor-cell selective targeting, ocular drug delivery, identification of the transporters appropriate for this purpose, and details of the rationale for the approach.
引用
收藏
页码:1 / 27
页数:27
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