A Proline-Tryptophan turn in the intrinsically disordered domain 2 of NS5A protein is essential for Hepatitis C virus RNA replication

被引:0
|
作者
Dujardin, Marie [1 ]
Madan, Vanesa [2 ]
Montserret, Roland [3 ]
Ahuja, Puneet [1 ]
Huvent, Isabelle [1 ]
Launay, Helene [1 ]
Bartenschlager, Ralf [2 ]
Penin, Francois [3 ]
Lippens, Guy [1 ]
Hanoulle, Xavier [1 ]
机构
[1] Univ Lille, CNRS, UMR 8576, UGSF, Lille, France
[2] Heidelberg Univ, Mol Virol, Dept Infect Dis, D-69115 Heidelberg, Germany
[3] Univ Lyon 1, CNRS, UMR 5086, IBCP,LabEx Ecofect, F-69622 Villeurbanne, France
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
PF-006
引用
收藏
页码:121 / 122
页数:2
相关论文
共 50 条
  • [1] A Proline-Tryptophan Turn in the Intrinsically Disordered Domain 2 of NS5A Protein Is Essential for Hepatitis C Virus RNA Replication
    Dujardin, Marie
    Madan, Vanesa
    Montserret, Roland
    Ahuja, Puneet
    Huvent, Isabelle
    Launay, Helene
    Leroy, Arnaud
    Bartenschlager, Ralf
    Penin, Franois
    Lippens, Guy
    Hanoulle, Xavier
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (31) : 19104 - 19120
  • [2] NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B
    Bessa, Luiza M.
    Launay, Helene
    Dujardin, Marie
    Cantrelle, Francois-Xavier
    Lippens, Guy
    Landrieu, Isabelle
    Schneider, Robert
    Hanoulle, Xavier
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 292 (44) : 18024 - 18043
  • [3] Domain III of NS5A contributes to both RNA replication and assembly of hepatitis C virus particles
    Hughes, Mair
    Griffin, Stephen
    Harris, Mark
    JOURNAL OF GENERAL VIROLOGY, 2009, 90 : 1329 - 1334
  • [4] A Hepatitis C Virus NS5A Phosphorylation Site That Regulates RNA Replication
    LeMay, K. L.
    Treadaway, J.
    Angulo, I.
    Tellinghuisen, T. L.
    JOURNAL OF VIROLOGY, 2013, 87 (02) : 1255 - 1260
  • [5] Interaction between Nonstructural Proteins NS4B and NS5A Is Essential for Proper NS5A Localization and Hepatitis C Virus RNA Replication
    Biswas, Avik
    Treadaway, Jason
    Tellinghuisen, Timothy L.
    JOURNAL OF VIROLOGY, 2016, 90 (16) : 7205 - 7218
  • [6] Effect of interaction between hepatitis C virus NS5A and NS5B on hepatitis C virus RNA replication with the hepatitis C virus replicon
    Shimakami, T
    Hijikata, M
    Luo, H
    Ma, YY
    Kaneko, S
    Shimotohno, K
    Murakami, S
    JOURNAL OF VIROLOGY, 2004, 78 (06) : 2738 - 2748
  • [7] Phosphorylation of NS5A Serine-235 is essential to hepatitis C virus RNA replication and normal replication compartment formation
    Eyre, Nicholas S.
    Hampton-Smith, Rachel J.
    Aloia, Amanda L.
    Eddes, James S.
    Simpson, Kaylene J.
    Hoffmann, Peter
    Beard, Michael R.
    VIROLOGY, 2016, 491 : 27 - 44
  • [8] A role for domain I of the hepatitis C virus NS5A protein in virus assembly
    Yin, Chunhong
    Goonawardane, Niluka
    Stewart, Hazel
    Harris, Mark
    PLOS PATHOGENS, 2018, 14 (01)
  • [9] A Conserved Proline between Domains II and III of Hepatitis C Virus NS5A Influences both RNA Replication and Virus Assembly
    Hughes, Mair
    Gretton, Sarah
    Shelton, Holly
    Brown, David D.
    McCormick, Christopher J.
    Angus, Allan G. N.
    Patel, Arvind H.
    Griffin, Stephen
    Harris, Mark
    JOURNAL OF VIROLOGY, 2009, 83 (20) : 10788 - 10796
  • [10] The Domain 2 of the HCV NS5A Protein Is Intrinsically Unstructured
    Hanoulle, Xavier
    Badillo, Aurelie
    Verdegem, Dries
    Penin, Francois
    Lippens, Guy
    PROTEIN AND PEPTIDE LETTERS, 2010, 17 (08): : 1012 - 1018