T-lymphocyte subsets, thymic size and breastfeeding in infancy

被引:49
|
作者
Jeppesen, DL
Hasselbalch, H
Lisse, IM
Ersboll, AK
Engelmann, MDM
机构
[1] Univ Copenhagen, Hvidovre Hosp, Dept Pediat, DK-2650 Hvidovre, Denmark
[2] Univ Copenhagen, Hvidovre Hosp, Dept Radiol, DK-2650 Hvidovre, Denmark
[3] Bandim Hlth Project, Danish Epidemiol Sci Ctr, Guinea Bissau, Denmark
[4] Royal Vet & Agr Univ, Res Dept Human Nut, DK-1870 Frederiksberg, Denmark
关键词
T-lymphocyte subsets; CD4+; CD8+; thymus; breastfeeding;
D O I
10.1111/j.1399-3038.2004.00032.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
We followed the changes in concentration of T-lymphocyte subsets (CD4+ and CD8+ cells) in peripheral blood and thymus size during infancy. Previous studies have found increased thymus size in breastfed infants. The present study analyzed the association between breastfeeding and the number of CD4+ and CD8+ cells. Two different populations of infants between birth and I year of age were examined. Study Group I: infants with a variable duration of breastfeeding. Study Group II: long-term breastfed infants. In both groups a correlation was found between CD8+ cells and the thymic index at 10 months of age. In Group I, infants still breastfed at the 8-month examination had a higher CD8% than formula-fed infants (p = 0.05), and infants breastfed at the 4-month examination had a higher CD4% at 10 months of age (p = 0.03). Group II showed an increase in the absolute number of CD4+ and CD8+ cells from 8 to 10 months of age; and a positive correlation between the number of breastfeedings per day at 8 months of age, and an increase in CD4+ cells from 8 to 10 months of age (p < 0.01). In conclusion, a correlation was found between thymus size and CD8+ cells. Breastfeeding might have both a current and long-term immune-modulating effect on the developing cellular immune system.
引用
收藏
页码:127 / 132
页数:6
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