Doomed from the TERT? A Two-Stage Model of Tumorigenesis in IDH-Wild-Type Glioblastoma

被引：10

作者：

Stead, Lucy F. ^{[1
]}

Verhaak, Roel G. W. ^{[2
]}

机构：

[1] Univ Leeds, Leeds Inst Med Res St Jamess, Leeds LS9 7TF, W Yorkshire, England

[2] Jackson Lab Genom Med, Farmington, CT 06032 USA

来源：

CANCER CELL | 2019年 / 35卷 / 04期

关键词：

TUMOR EVOLUTION;

D O I：

10.1016/j.ccell.2019.03.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Using longitudinal molecular profiling, Korber et al. propose in this issue of Cancer Cell that IDH-wild-type glioblastomas initiate years pre-diagnosis with chromosome-level alterations that drive cell proliferation but require survival-promoting mutations, commonly in the TERT promoter, to form a detectable tumor. Multiple subclones drive disease progression, creating a therapeutic challenge.

引用

页码：542 / 544

页数：3

共 50 条

[41] Development and external validation of a clinical prediction model for survival in patients with IDH wild-type glioblastoma
Mijderwijk, Hendrik-Jan
Nieboer, Daan
Incekara, Fatih
Berger, Kerstin
Steyerberg, Ewout W.
van den Bent, Martin J.
Reifenberger, Guido
Hanggi, Daniel
Smits, Marion
Senft, Christian
Rapp, Marion
Sabel, Michael
Voss, Martin
Forster, Marie-Therese
Kamp, Marcel A.
JOURNAL OF NEUROSURGERY, 2022, 137 (04) : 914 - 923
[42] Low co-expression of epidermal growth factor receptor and its chaperone heat shock protein 90 is associated with worse prognosis in primary glioblastoma, IDH-wild-type
Sartori, Elsa
Langer, Rupert
Vassella, Erik
Hewer, Ekkehard
Schucht, Philipe
Zlobec, Inti
Berezowska, Sabina
ONCOLOGY REPORTS, 2017, 38 (04) : 2394 - 2400
[43] Human TERT promoter mutation enables survival advantage from MGMT promoter methylation in IDH1 wild-type primary glioblastoma treated by standard chemoradiotherapy
Nguyen, HuyTram N.
Lie, Amy
Li, Tie
Chowdhury, Reshmi
Liu, Fei
Ozer, Byram
Wei, Bowen
Green, Richard M.
Ellingson, Benjamin M.
Wang, He-jing
Elashoff, Robert
Liau, Linda M.
Yong, William H.
Nghiemphu, Phioanh L.
Cloughesy, Timothy
Lai, Albert
NEURO-ONCOLOGY, 2017, 19 (03) : 394 - 404
[44] Prognostic role and interaction of TERT promoter status, telomere length and MGMT promoter methylation in newly diagnosed IDH wild-type glioblastoma patients
Giunco, S.
Padovan, M.
Angelini, C.
Cavallin, F.
Cerretti, G.
Morello, M.
Caccese, M.
Rizzo, B.
d'Avella, D.
Puppa, A. D.
Chioffi, F.
De Bonis, P.
Zagonel, V.
De Rossi, A.
Lombardi, G.
ESMO OPEN, 2023, 8 (03)
[45] TWO-STAGE MODEL FOR SOCIAL RELATIONSHIP UNDERSTANDING FROM VIDEOS
Dai, Pilin
Lv, Jinna
Wu, Bin
2019 IEEE INTERNATIONAL CONFERENCE ON MULTIMEDIA AND EXPO (ICME), 2019, : 1132 - 1137
[46] A Two-Stage Thermotectonic Model for the Athabasca Unconformity-Type Uranium Deposits
Pana, Dinu
DIGGING DEEPER, VOLS 1 AND 2: DIGGING DEEPER, 2007, : 1133 - 1136
[47] MAPPING TUMOR HABITATS IN IDH-WILD TYPE GLIOBLASTOMA: INTEGRATING MR IMAGING, PATHOLOGIC, AND RNA DATA FROM IVY GLIOBLASTOMA ATLAS PROJECT
Park, Ji Eun
Lee, Ho-Su
Lee, Dongjun
Yoon, Shinkyo
Song, Sang Woo
Kim, Young-Hoon
Hong, Chang Ki
Kim, Jeong Hoon
Kim, Ho Sung
NEURO-ONCOLOGY, 2024, 26
[48] The symmetric type two-stage trimmed least squares estimator for the simultaneous equations model
Chen, LA
Thompson, P
Hung, HN
STATISTICA SINICA, 2000, 10 (04) : 1243 - 1255
[49] A two-stage evolution model for the Amantaytau orogenic-type gold deposit in Uzbekistan
Pasava, Jan
Frimmel, Hartwig
Vymazalova, Anna
Dobes, Petr
Jukov, Alexandr V.
Koneev, Rustam I.
MINERALIUM DEPOSITA, 2013, 48 (07) : 825 - 840
[50] A two-stage evolution model for the Amantaytau orogenic-type gold deposit in Uzbekistan
Jan Pasava
Hartwig Frimmel
Anna Vymazalová
Petr Dobes
Alexandr V. Jukov
Rustam I. Koneev
Mineralium Deposita, 2013, 48 : 825 - 840

← 1 2 3 4 5 →