Therapeutic targeting of the p53 pathway in cancer stem cells

被引：35

作者：

Prabhu, Varun V. ^{[1
]}

Allen, Joshua E. ^{[1
,2
]}

Hong, Bo ^{[1
]}

Zhang, Shengliang ^{[1
]}

Cheng, Hairong ^{[1
]}

El-Deiry, Wafik S. ^{[1
]}

机构：

[1] Penn State Coll Med, Penn State Hershey Canc Inst, Dept Med Hematol Oncol, Lab Translat Oncol & Expt Canc Therapeut, Hershey, PA 17033 USA

[2] Univ Penn, Sch Med, Biochem & Mol Biophys Grad Grp, Philadelphia, PA 19104 USA

来源：

EXPERT OPINION ON THERAPEUTIC TARGETS | 2012年 / 16卷 / 12期

关键词：

cancer; cancer stem cells; cancer therapy; p53; pathway; p53 pathway restoration; restoration; stem cells; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR-SUPPRESSOR; HEMATOPOIETIC STEM; SIDE POPULATION; SELF-RENEWAL; RESTORATION; NOTCH; DIFFERENTIATION; ACTIVATION; REPRESSION;

D O I：

10.1517/14728222.2012.726985

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Introduction: Cancer stem cells (CSCs) are a high profile drug target for cancer therapeutics due to their indispensable role in cancer progression, maintenance and therapeutic resistance. Restoring wild-type (WT) p53 function is an attractive new therapeutic approach for the treatment of cancer due to the well-described powerful tumor suppressor function of p53. As emerging evidence intimately links p53 and stem cell biology, this approach also provides an opportunity to target CSCs. Areas covered: This review covers the therapeutic approaches to restore the function of WT p53, cancer and normal stem cell biology in relation to p53 and the downstream effects of p53 on CSCs. Expert opinion: The restoration of WT p53 function by targeting p53 directly, its interacting proteins or its family members holds promise as a new class of cancer therapies. This review examines the impact that such therapies may have on normal and CSCs based on the current evidence linking p53 signaling with these populations.

引用

页码：1161 / 1174

页数：14

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