Synthesis, Characterization, Anticancer and Antimicrobial Activity Studies of Novel Isomeric 2,4-Disubstituted Ureide Derivatives of Pyrimidinopiperidines

被引：3
|
作者：
Bhavanam, Lourdu Rani [1 ]
Kotra, Vijay [2 ]
Mule, Sivanagi Reddy [1 ]
Khandapu, Bala Murali Krishna [1 ]
Bollikolla, Hari Babu [1 ]
机构：
[1] Acharya Nagarjuna Univ, Dept Chem, Guntur, Andhra Pradesh, India
[2] Quest Int Univ Perak, Ctr Pharmaceut Res & Postgrad Studies, Fac Pharm, Ipoh 30250, Malaysia
来源：
CHEMISTRYSELECT | 2019年 / 4卷 / 01期
关键词：
Anticancer activity; Antimicrobial activity; pyrimidine; Ureide derivatives * Piperidine derivatives; ANTIBACTERIAL; ALKALOIDS; DESIGN; POTENT;
D O I：
10.1002/slct.201803294
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of isomeric ureide derivatives of novel 2,4-disubstituted pyrimidinopiperidines were synthesized starting from 2,4-dichloropyrimidine. All the final products were purified on silica and characterized by spectral analysis. Both the 2,4-disubstituted pyrimidinopiperidines were analyzed for their in vitro anticancer activity on the cell lines HCT116, MIA-PaCa2 and MDA-MB 231 by using MTT cell proliferation assay. Further, the antimicrobial studies were carried out against different bacterial and fungal strains by employing cup plate method. These compounds were showed significant anticancer activity on tested three cancer cell lines and exhibited potent antimicrobial activity in tested strains of bacteria and fungi.
引用
收藏
页码：441 / 450
页数：10
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