Association between variations in the disrupted in schizophrenia 1 gene and schizophrenia: A meta-analysis

被引：10
|
作者：
Xu, Yiliang [1 ]
Ren, Jun [1 ]
Ye, Haihong [1 ]
机构：
[1] Capital Med Univ, Dept Med Genet & Dev Biol, Sch Basic Med Sci, Beijing Inst Brain Disorders,Ctr Schizophrenia, Beijing 100069, Peoples R China
来源：
GENE | 2018年 / 651卷
基金：
中国国家自然科学基金; 北京市自然科学基金;
关键词：
DISC1; Polymorphisms; Schizophrenia; Meta-analysis; MAJOR MENTAL-ILLNESS; DISC1; GENE; JAPANESE POPULATION; CHINESE POPULATION; PSYCHIATRIC GENETICS; SCOTTISH POPULATION; IMMUNE ACTIVATION; BIPOLAR DISORDER; HAN CHINESE; RISK-FACTOR;
D O I：
10.1016/j.gene.2018.01.069
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Schizophrenia is a severe psychiatric disorder. Genetic and functional studies have strongly implicated the disrupted in schizophrenia 1 gene (DISCI) as a candidate susceptibility gene for schizophrenia. Moreover, recent association studies have indicated that several DISCI single nucleotide polymorphisms (SNPs) are associated with schizophrenia. However, the association is hardly replicate in different ethnic group. Here, we performed a meta-analysis of the association between DISCI SNPs and schizophrenia in which the samples were divided into subgroups according to ethnicity. Both rs3738401 and rs821616 showed not significantly association with schizophrenia in the Caucasian, Asian, Japanese or Han Chinese populations.
引用
收藏
页码：94 / 99
页数：6
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