MicroGMT: A Mutation Tracker for SARS-CoV-2 and Other Microbial Genome Sequences

被引:21
|
作者
Xing, Yue [1 ]
Li, Xiao [2 ]
Gao, Xiang [3 ]
Dong, Qunfeng [3 ,4 ]
机构
[1] Texas A&M Univ, Dept Vet Integrat Biosci, College Stn, TX USA
[2] Texas A&M Univ, Dept Mol & Cellular Med, College Stn, TX USA
[3] Loyola Univ Chicago, Stritch Sch Med, Dept Med, Maywood, IL 60660 USA
[4] Loyola Univ Chicago, Ctr Biomed Informat, Stritch Sch Med, Maywood, IL 60660 USA
关键词
COVID-19; SARS-CoV-2; molecular evolution; epidemiology; bioinformatics; mutation; microbial; virus; FRAMEWORK;
D O I
10.3389/fmicb.2020.01502
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
With the continued spread of SARS-CoV-2 virus around the world, researchers often need to quickly identify novel mutations in newly sequenced SARS-CoV-2 genomes for studying the molecular evolution and epidemiology of the virus. We have developed a Python package, MicroGMT, which takes either raw sequence reads or assembled genome sequences as input and compares against database sequences to identify and characterize indels and point mutations. Although our default setting is optimized for SARS-CoV-2 virus, the package can be also applied to any other microbial genomes. The software is freely available at Github URL https://github.com/qunfengdong/MicroGMT.
引用
收藏
页数:4
相关论文
共 50 条
  • [21] The UCSC SARS-CoV-2 Genome Browser
    Jason D. Fernandes
    Angie S. Hinrichs
    Hiram Clawson
    Jairo Navarro Gonzalez
    Brian T. Lee
    Luis R. Nassar
    Brian J. Raney
    Kate R. Rosenbloom
    Santrupti Nerli
    Arjun A. Rao
    Daniel Schmelter
    Alastair Fyfe
    Nathan Maulding
    Ann S. Zweig
    Todd M. Lowe
    Manuel Ares
    Russ Corbet-Detig
    W. James Kent
    David Haussler
    Maximilian Haeussler
    Nature Genetics, 2020, 52 : 991 - 998
  • [22] SARS-CoV-2 has stable genome
    Howes, Laura
    CHEMICAL & ENGINEERING NEWS, 2020, 98 (34) : 5 - 5
  • [23] CoVe-Tracker: An Interactive SARS-CoV-2 Pan Proteome Evolution Tracker
    Sathyaseelan, Chakkarai
    Saras, Murali Aadhitya Magateshvaren
    Patro, L. Ponoop Prasad
    Uttamrao, Patil Pranita
    Rathinavelan, Thenmalarchelvi
    JOURNAL OF PROTEOME RESEARCH, 2023, 22 (06) : 1984 - 1996
  • [24] Four SARS-CoV-2 Genome Sequences from Late April in Stockholm, Sweden, Reveal a Rare Mutation in the Spike Protein
    Soratto, Tatiany Aparecida Teixeira
    Darban, Hamid
    Bjerkner, Annelie
    Coorens, Maarten
    Albert, Jan
    Allander, Tobias
    Andersson, Bjorn
    MICROBIOLOGY RESOURCE ANNOUNCEMENTS, 2020, 9 (35):
  • [25] An integrated approach to determine the abundance, mutation rate and phylogeny of the SARS-CoV-2 genome
    Desai, Sanket
    Rashmi, Sonal
    Rane, Aishwarya
    Dharavath, Bhasker
    Sawant, Aniket
    Dutt, Amit
    BRIEFINGS IN BIOINFORMATICS, 2021, 22 (02) : 1065 - 1075
  • [26] Assessment of intercontinents mutation hotspots and conserved domains within SARS-CoV-2 genome
    Omotoso, Olabode E.
    Olugbami, Jeremiah O.
    Gbadegesin, Michael A.
    INFECTION GENETICS AND EVOLUTION, 2021, 96
  • [27] Tracing SARS-CoV-2 ... and other stories
    不详
    BMJ-BRITISH MEDICAL JOURNAL, 2022, 376
  • [28] Cov2clusters: genomic clustering of SARS-CoV-2 sequences
    Benjamin Sobkowiak
    Kimia Kamelian
    James E. A. Zlosnik
    John Tyson
    Anders Gonçalves da Silva
    Linda M. N. Hoang
    Natalie Prystajecky
    Caroline Colijn
    BMC Genomics, 23
  • [29] Cov2clusters: genomic clustering of SARS-CoV-2 sequences
    Sobkowiak, Benjamin
    Kamelian, Kimia
    Zlosnik, James E. A.
    Tyson, John
    da Silva, Anders Goncalves
    Hoang, Linda M. N.
    Prystajecky, Natalie
    Colijn, Caroline
    BMC GENOMICS, 2022, 23 (01)
  • [30] Full genome viral sequences inform patterns of SARS-CoV-2 spread into and within Israel
    Miller, Danielle
    Martin, Michael A.
    Harel, Noam
    Tirosh, Omer
    Kustin, Talia
    Meir, Moran
    Sorek, Nadav
    Gefen-Halevi, Shiraz
    Amit, Sharon
    Vorontsov, Olesya
    Shaag, Avraham
    Wolf, Dana
    Peretz, Avi
    Shemer-Avni, Yonat
    Roif-Kaminsky, Diana
    Kopelman, Naama M.
    Huppert, Amit
    Koelle, Katia
    Stern, Adi
    NATURE COMMUNICATIONS, 2020, 11 (01)