FoxO1: mute for a tuned metabolism?

被引：13
|
作者：
Cheng, Zhiyong [1 ]
机构：
[1] Virginia Tech, Dept Human Nutr Foods & Exercise, Fralin Translat Obes Res Ctr, Coll Agr & Life Sci, Blacksburg, VA 24061 USA
来源：
TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2015年 / 26卷 / 08期
关键词：
FoxO1; insulin signaling; insulin resistance; glucose; lipid; metabolic homeostasis; HEPATIC GLUCOSE; IN-VIVO; INSULIN; LIVER;
D O I：
10.1016/j.tem.2015.06.006
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The transcription factor forkhead box O1 (FoxO1) plays pleiotropic roles in insulin-mediated glucose and lipid metabolism. In the liver, glucose production is finely controlled by insulin signaling that dampens FoxO1. Two recent studies show that silencing of FoxO1 is also essential for extra-hepatic insulin signaling to maintain glucose homeostasis.
引用
收藏
页码：402 / 403
页数：2
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