Genetic relationship between IL-10 gene polymorphisms and the risk of clinical atopic dermatitis

BackgroundWe retrieved different reports containing different genetic effects of -1082 A/G, -819T/C, and-592 A/C polymorphisms within the IL-10 (interleukin-10) gene on the susceptibility to clinical atopic dermatitis.MethodsHerein, we conducted a meta-analysis to comprehensively assess such a genetic relationship after collecting the available published evidence. STATA 12.0 software was used for the statistical analysis under the allelic, homozygotic, heterozygotic, dominant, recessive and carrier genetic models.ResultsBy retrieving and screening database literature, a total of 16 eligible case-control studies were finally selected. For the IL-10 -1082 A/G polymorphism, we did not detect a significant difference between atopic dermatitis cases and population-based controls in the overall meta-analysis under the genetic models of allele G vs. A (P=0.540), GG vs. AA (P=0.853), AG vs AA (P=0.265), AG+GG vs AA (P=0.221), GG vs AA+AG (P=0.540) and carrier G vs. A (P=0.643). Moreover, a statistically non-significant association was observed in the most subgroup meta-analyses by the factors of ethnicity, country and Hardy-Weinberg equilibrium. Likewise, the negative results were detected for the synthetic analysis of IL-10 -819T/C and-592 C/A polymorphisms.ConclusionThe current evidence does not support a strong genetic relationship between IL-10 -1082 A/G, -819T/C and-592 A/C polymorphisms and the susceptibility to atopic dermatitis.